J Clin Neurol.
2024 Mar;20(2):208-213. 10.3988/jcn.2022.0257.
Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study
- Affiliations
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- 1Departments of Neurology, Kangwon National University Hospital, Chuncheon, Korea
- 2Departments of Medical Bigdata Convergence Statistics, Kangwon National University, Chuncheon, Korea
- 3Departments of Statistics, Kangwon National University, Chuncheon, Korea
- 4Departments of Psychiatry, Kangwon National University Hospital, Chuncheon, Korea
- 5Departments of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea
- 6Departments of Neurology, Kangwon National University School of Medicine, Chuncheon, Korea
- KMID: 2553482
- DOI: http://doi.org/10.3988/jcn.2022.0257
Abstract
- Background and Purpose
The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.
Methods
We reconstructed a population-based matched cohort from the National Health Insurance Service—Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.
Results
Overall 53,776 subjects with lower-body fractures were identified during 2006–2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lowerbody fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49–1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14–1.23).
Conclusions
These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.
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