Korean J Transplant.  2023 Nov;37(Suppl 1):S84. 10.4285/ATW2023.F-6674.

24-hour urine sodium excretion among renal donors in India: a cross-sectional study

• LV KB
• Kannabhiran D
• Raj Y
• Arumugam K
• Ravichandran R

• KMID: 2551671
• DOI: http://doi.org/10.4285/ATW2023.F-6674

Abstract

Background
High sodium intake is associated with increased risk of hypertension, stroke and cardiovascular disease. Renal donors, with reduced nephron mass, are a vulnerable population with higher risk of hypertension and other comorbidities. There is paucity of literature to assess urinary sodium excretion among renal donors.
Methods
This is a descriptive cross-sectional study of renal donors who came for follow up to MIOT International Hospital from 2019–2021. Sodium excretion was assessed through collection of 24-hour urine and their clinical information was ob-tained through chart review.
Results
Out of the 104 donors who came for a follow-up visit, 82 donors had a 24-hour urine measurement obtained. Among these donors, 83% of them were females and the mean age at donation was 45.5 years. The median follow-up was 4 years (range, 1–27 years). Mean estimated glomerular filtration rate (eGFR) decreased from 108±14.4 mL/min/1.73 m² at the time of donation to 81.4±21.4 mL/min/1.73 m² during follow up visit (P<0.0001). The mean 24-hour salt excretion among donors was 9.2±4.8 g /day. The mean 24-hour salt excretion was similar between various subgroups: male vs. female (10.9±4.8 vs. 8.7±4.1 g/day, P=0.07), hypertensive vs. nonhypertensive (9.2±4.8 vs. 8.9±4.1 g/day, P=0.8) and donors with eGFR <60 vs. >60 mL/min/1.73 m ² (7.6±2.2 vs. 9.3±4.2 g/day, P=0.2). Only 10 out of 82 donors had salt intake less than 5 g/day. More than WHO recommendations (>5 g/day) for salt intake were observed in 87% of the cases.
Conclusions
In conclusion, estimated salt intake is much higher than WHO recommendations in a majority of the renal donors. Physicians should counsel on reducing salt intake in this population.