Allergy Asthma Respir Dis.  2023 Oct;11(4):211-215. 10.4168/aard.2023.11.4.211.

Whole lung lavage with granulocyte macrophage colony-stimulating factor inhalation in children with pulmonary alveolar proteinosis: A case report

  • 1Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
  • 2Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
  • 3Department of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
  • 4Department of Pediatrics, Gyeoungsang National University Changwon Hospital, Changwon, Korea


Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by hypoxemic respiratory failure due to the accumulation of lipoproteinaceous material in alveolar macrophages and alveoli. It has been reported that granulocyte macrophage colony-stimulating factor (GM-CSF) inhalation or whole lung lavage significantly improves the disease state. We present a case of 17-year-old female diagnosed with PAP and treated with both GM-CSF inhalation and whole lung lavage. Her symptoms, imaging findings, and pulmonary function tests improved after these treatments. Therefore, combined treatments of whole lung lavage and subsequent GM-CSF inhalation should be considered a treatment option for children and adolescents.


Pulmonary alveolar proteinosis; Whole lung lavage; Granulocyte macrophage colony-stimulating factor inhalation; Child
Full Text Links
  • AARD
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: