J Korean Acad Oral Health.  2023 Jun;47(2):51-57. 10.11149/jkaoh.2023.47.2.51.

Effect of a mouthwash containing cetylpyridinium chloride and zinc acetate

• Mun YR
• Choi GB
• Kim DH
• Cho JW
• Yea JS

• KMID: 2543910
• DOI: http://doi.org/10.11149/jkaoh.2023.47.2.51

Abstract

Objectives
This study investigated the effects of mouthwashes containing cetylpyridinium chloride and zinc acetate on oral health.
Methods
A total of 60 participants were included in the study. Fifty-three participants (27 and 26 participants in the experimental and control groups, respectively) were retained, excluding seven candidates who dropped out. The mouthwash used for the study was spat out after 10-15 ml of mouth-washing for 3 s in the oral cavity after breakfast, lunch, and dinner. Oral examination indices included the gingival (gingival index, PMA index), the patient hygiene performance (PHP index, Turesky plaque index), and the bad breath (BB checker, Oral chroma) indices. Five measurements were taken after 2, 4, 6, 8, and 12 weeks and compared.
Results
Measurements of the gingival index showed a statistically significant difference between the experimental and the control groups after 4 weeks, and the PMA index from eight weeks (P<0.05). Measurements of the PHP and Turesky plaque indices showed a significant difference in the experimental and control groups after 4 weeks (P<0.05). Compared to the PHP index before the experiment, that of the experimental group showed a significant index decrease after 2 weeks (P<0.05). Results of measuring bad breath through a BB checker showed a statistically significant difference between the experimental and control groups after 4 weeks (P<0.05).
Conclusions
Oral mouthwash products containing cetylpyridinium chloride and zinc acetate relieves gingivitis, removes bacterial plaque, and reduces bad breath.

Keyword

Cetylpyridinium chloride; Mouthwash; Zinc acetate