J Korean Soc Clin Toxicol.  2023 Jun;21(1):32-38. 10.22537/jksct.2023.00004.

Changes in deoxyhemoglobin and admission duration in carbon monoxide poisoning patients: a retrospective study

• Ji JG
• Kim YW
• Park CH
• Yoon YS
• Jang Y
• Kang JH
• Park CM
• Park SH

• KMID: 2543424
• DOI: http://doi.org/10.22537/jksct.2023.00004

Abstract

Purpose
The purpose of this study was to determine whether deoxyhemoglobin changes were associated with admission duration in carbon monoxide (CO)-poisoned patients.
Methods
This retrospective study included 181 patients who were able to breathe by themselves after CO poisoning. Arterial blood gas analysis was performed to measure their deoxyhemoglobin levels. Their baseline characteristics and clinical outcomes during hospitalization in the emergency department (ED) were collected and compared. To assess changes in deoxyhemoglobin levels, blood samples were taken immediately after patients presented to the ED and then again after 6 hours. For statistical analysis, logistic regression was utilized to determine the effect of deoxyhemoglobin changes on admission duration.
Results
The incidence rates of hypocapnia and hypoxemia at presentation after acute CO poisoning were 28.7% and 43.6%, respectively. Moreover, the magnitude of increasing deoxyhemoglobin levels in patients with hypoxemia (2.1 [1.7–3.1], p<0.001) and changes in deoxyhemoglobin levels appeared to have an impact on the length of hospitalization in the ED (odds ratio, 1.722; 95% confidence interval, 0.547–0.952; p<0.001).
Conclusion
In patients with acute CO poisoning, deoxyhemoglobin levels appeared to increase in those with hypoxemia, which in turn was associated with prolonged hospitalization.

Keyword

Deoxyhemoglobin; Hypoxemia; Carbon monoxide; Poisoning; Blood gas analysis