J Neurocrit Care.  2023 Jun;16(1):53-54. 10.18700/jnc.230005.

Anti-N-methyl-D-aspartate receptor encephalitis after resection of cerebral astrocytoma

Affiliations
  • 1Department of Neurology, Inje University Busan Paik Hospital, Busan, Korea
  • 2Department of Neurology, Kyung Hee University Hospital, Seoul, Korea


Figure

  • Fig. 1. Brain magnetic resonance imaging (MRI). Brain MRI showed an ill-defined, mass-like lesion (arrow) with high signal intensities at right basal ganglia, insula, external capsule, the temporal lobe on fluid-attenuated inversion recovery (FLAIR) image (A) and irregular enhancement (arrow) on axial contrast-enhanced T1-weighted image (B). (C) MR spectroscopy showed the slightly increased value of choline to creatine ratio and decreased value of N-acetylaspartate peak at the mass-like lesion involving right basal ganglia, insula, external capsule, and temporal lobe, suggesting tumorous condition (red square: volume of interest). (D) In the postoperative follow-up MRI, FLAIR showed remained tumor (arrow) and postoperative hemorrhage (arrowhead) on the right temporal lobe. After 3 months with seizure presentation, diffusion-weighted image (E) and FLAIR (F) showed newly occurred, multifocal hyperintense lesions (arrowheads) at left temporoparietal lobes.


Reference

1. Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol. 2019; 18:1045–57.
2. Beretta F, Aliprandi A, Di Leo C, Salmaggi A. A case of anti-N-methyl-D-aspartate receptor encephalitis associated with glioma of the pons. J Clin Neurol. 2019; 15:125–7.
3. Bost C, Chanson E, Picard G, Meyronet D, Mayeur ME, Ducray F, et al. Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies. J Neurol. 2018; 265:2190–200.
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