Korean J healthc assoc Infect Control Prev.  2023 Jun;28(1):36-41. 10.14192/kjicp.2023.28.1.36.

Hemodialysis Catheter-associated Infections: From Prevention to Treatment

Affiliations
  • 1Division of Nephrology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea

Abstract

Central venous catheter-related infection is associated with increased morbidity and mortality among patients undergoing hemodialysis. This review summarizes the management and prevention of hemodialysis catheter-related infections with reference to the previous guidelines. The management of these infections involves appropriate cultures, empiric antibiotic treatment, a change in antibiotics according to culture sensitivities, and decisions on catheter removal. Prevention of these infections includes the location of catheter placement, type of catheter, monitoring/surveillance of catheter complications, care of exit site, and selective use of prophylactic locking with antibiotic, antimicrobial, or thrombolytic agents in patients at high risk of catheter-related bloodstream infections.

Keyword

Catheter-related infection; Hemodialysis; Management; Prevention

Figure

  • Fig. 1 Algorithm for management of CVC-related bloodstream infection. Abbreviation: CVC, central venous catheter.


Reference

1. Lok CE, Huber TS, Lee T, Shenoy S, Yevzlin AS, Abreo K, et al. 2020; KDOQI Clinical Practice Guideline for Vascular Access: 2019 update. Am J Kidney Dis. 75:S1–S164. Erratum in: Am J Kidney Dis 2021;77:551. DOI: 10.1053/j.ajkd.2021.02.002. PMID: 33752805.
Article
2. Saran R, Robinson B, Abbott KC, Agodoa LYC, Bragg-Gresham J, Balkrishnan R, et al. 2019; US Renal Data System 2018 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 73(3 Suppl 1):A7–8. DOI: 10.1053/j.ajkd.2019.01.001. PMID: 30798791. PMCID: PMC6620109.
3. Nguyen DB, Shugart A, Lines C, Shah AB, Edwards J, Pollock D, et al. 2017; National Healthcare Safety Network (NHSN) Dialysis Event Surveillance report for 2014. Clin J Am Soc Nephrol. 12:1139–46. DOI: 10.2215/CJN.11411116. PMID: 28663227. PMCID: PMC5498356.
Article
4. Poinen K, Quinn RR, Clarke A, Ravani P, Hiremath S, Miller LM, et al. 2019; Complications from tunneled hemodialysis catheters: a Canadian observational cohort study. Am J Kidney Dis. 73:467–75. DOI: 10.1053/j.ajkd.2018.10.014. PMID: 30642607.
Article
5. Ravani P, Palmer SC, Oliver MJ, Quinn RR, MacRae JM, Tai DJ, et al. 2013; Associations between hemodialysis access type and clinical outcomes: a systematic review. J Am Soc Nephrol. 24:465–73. DOI: 10.1681/ASN.2012070643. PMID: 23431075. PMCID: PMC3582202.
6. Marr KA, Sexton DJ, Conlon PJ, Corey GR, Schwab SJ, Kirkland KB. 1997; Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis. Ann Intern Med. 127:275–80. DOI: 10.7326/0003-4819-127-4-199708150-00003. PMID: 9265426.
Article
7. Lok CE, Mokrzycki MH. 2011; Prevention and management of catheter-related infection in hemodialysis patients. Kidney In. 79:587–98. DOI: 10.1038/ki.2010.471. PMID: 21178979.
Article
8. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, et al. 2009; Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 49:1–45. Erratum in: Clin Infect Dis 2010;50:457. DOI: 10.3410/f.1163875.625704. PMID: 19489710. PMCID: PMC4039170.
Article
9. Safdar N, Maki DG. 2002; Inflammation at the insertion site is not predictive of catheter-related bloodstream infection with short-term, noncuffed central venous catheters. Crit Care Med. 30:2632–5. DOI: 10.1097/00003246-200212000-00003. PMID: 12483050.
Article
10. Raad I, Hanna HA, Alakech B, Chatzinikolaou I, Johnson MM, Tarrand J. 2004; Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med. 140:18–25. DOI: 10.7326/0003-4819-140-1-200401060-00007. PMID: 14706968.
Article
11. Chatzinikolaou I, Hanna H, Hachem R, Alakech B, Tarrand J, Raad I. 2004; Differential quantitative blood cultures for the diagnosis of catheter-related bloodstream infections associated with short- and long-term catheters: a prospective study. Diagn Microbiol Infect Dis. 50:167–72. DOI: 10.1016/j.diagmicrobio.2004.07.007. PMID: 15541601.
Article
12. Safdar N, Fine JP, Maki DG. 2005; Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med. 142:451–66. Erratum in: Ann Intern Med 2005;142:803. DOI: 10.7326/0003-4819-142-6-200503150-00011. PMID: 15767623.
Article
13. Miller LM, Clark E, Dipchand C, Hiremath S, Kappel J, Kiaii M, et al. Canadian Society of Nephrology Vascular Access Work Group. 2016; Hemodialysis tunneled catheter-related infections. Can J Kidney Health Dis. 3:2054358116669129. DOI: 10.1177/2054358116669129. PMID: 28270921. PMCID: PMC5332080.
Article
14. Beathard GA. 1999; Management of bacteremia associated with tunneled-cuffed hemodialysis catheters. J Am Soc Nephrol. 10:1045–9. DOI: 10.1681/ASN.V1051045. PMID: 10232691.
Article
15. Nguyen DB, Lessa FC, Belflower R, Mu Y, Wise M, Nadle J, et al. Active Bacterial Core Surveillance (ABCs) MRSA Investigators of the Emerging Infections Program. 2013; Invasive methicillin-resistant Staphylococcus aureus infections among patients on chronic dialysis in the United States, 2005-2011. Clin Infect Dis. 57:1393–400. DOI: 10.1093/cid/cit546. PMID: 23964088. PMCID: PMC3805174.
Article
16. Danese MD, Griffiths RI, Dylan M, Yu HT, Dubois R, Nissenson AR. 2006; Mortality differences among organisms causing septicemia in hemodialysis patients. Hemodial Int. 10:56–62. DOI: 10.1111/j.1542-4758.2006.01175.x. PMID: 16441828.
Article
17. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Healthcare Infection Control Practices Advisory Committee (HICPAC). 2011; Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 52:e162–93. DOI: 10.1093/cid/cir257. PMID: 21460264. PMCID: PMC3106269.
18. Raad I, Davis S, Khan A, Tarrand J, Elting L, Bodey GP. 1992; Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect Control Hosp Epidemiol. 13:215–21. DOI: 10.2307/30147100. PMID: 1593102.
Article
19. Capdevila JA, Segarra A, Planes AM, Ramírez-Arellano M, Pahissa A, Piera L, et al. 1993; Successful treatment of haemodialysis catheter-related sepsis without catheter removal. Nephrol Dial Transplant. 8:231–4. DOI: 10.1093/oxfordjournals.ndt.a092437. PMID: 8385290.
20. Allon M. 2004; Dialysis catheter-related bacteremia: treatment and prophylaxis. Am J Kidney Dis. 44:779–91. DOI: 10.1016/S0272-6386(04)01078-9. PMID: 15492943.
Article
21. Vanholder R, Canaud B, Fluck R, Jadoul M, Labriola L, Marti-Monros A, et al. 2010; Diagnosis, prevention and treatment of haemodialysis catheter-related bloodstream infections (CRBSI): a position statement of European Renal Best Practice (ERBP). NDT Plus. 3:234–46. DOI: 10.1093/ndtplus/sfq041. PMID: 30792802. PMCID: PMC6371390.
22. Weijmer MC, Vervloet MG, ter Wee PM. 2004; Compared to tunnelled cuffed haemodialysis catheters, temporary untunnelled catheters are associated with more complications already within 2 weeks of use. Nephrol Dial Transplant. 19:670–7. DOI: 10.1093/ndt/gfg581. PMID: 14767025.
Article
23. Lee T, Barker J, Allon M. 2005; Tunneled catheters in hemodialysis patients: reasons and subsequent outcomes. Am J Kidney Dis. 46:501–8. DOI: 10.1053/j.ajkd.2005.05.024. PMID: 16129212.
Article
24. Vanholder R, Canaud B, Fluck R, Jadoul M, Labriola L, Marti-Monros A, et al. 2010; Catheter-related blood stream infections (CRBSI): a European view. Nephrol Dial Transplant. 25:1753–6. DOI: 10.1093/ndt/gfq205. PMID: 20466662.
Article
25. McIntyre CW, Hulme LJ, Taal M, Fluck RJ. 2004; Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney Int. 66:801–5. DOI: 10.1111/j.1523-1755.2004.00806.x. PMID: 15253736.
Article
26. Zhang P, Yuan J, Tan H, Lv R, Chen J. 2009; Successful prevention of cuffed hemodialysis catheter-related infection using an antibiotic lock technique by strictly catheter-restricted antibiotic lock solution method. Blood Purif. 27:206–11. DOI: 10.1159/000197560. PMID: 19176949.
Article
27. Hemmelgarn BR, Moist LM, Lok CE, Tonelli M, Manns BJ, Holden RM, et al. Prevention of Dialysis Catheter Lumen Occlusion with rt-PA versus Heparin Study Group. 2011; Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator. N Engl J Med. 364:303–12. DOI: 10.1056/NEJMoa1011376. PMID: 21268722.
Article
28. Maki DG, Ash SR, Winger RK, Lavin P. AZEPTIC Trial Investigators. 2011; A novel antimicrobial and antithrombotic lock solution for hemodialysis catheters: a multi-center, controlled, randomized trial. Crit Care Med. 39:613–20. DOI: 10.1097/CCM.0b013e318206b5a2. PMID: 21200319.
Article
29. Moghaddas A, Abbasi MR, Gharekhani A, Dashti-Khavidaki S, Razeghi E, Jafari A, et al. 2015; Prevention of hemodialysis catheter-related blood stream infections using a cotrimoxazole-lock technique. Future Microbiol. 10:169–78. DOI: 10.2217/fmb.14.116. PMID: 25689529.
Article
30. Landry DL, Braden GL, Gobeille SL, Haessler SD, Vaidya CK, Sweet SJ. 2010; Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis. Clin J Am Soc Nephrol. 5:1799–804. DOI: 10.2215/CJN.01270210. PMID: 20595689. PMCID: PMC2974380.
Article
31. James MT, Conley J, Tonelli M, Manns BJ, MacRae J, Hemmelgarn BR. 2008; Meta-analysis: antibiotics for prophylaxis against hemodialysis catheter-related infections. Ann Intern Med. 148:596–605. DOI: 10.7326/0003-4819-148-8-200804150-00004. PMID: 18413621.
Article
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