Clin Psychopharmacol Neurosci.
2023 May;21(2):386-390. 10.9758/cpn.2023.21.2.386.
Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
- Affiliations
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- 1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
- 2Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea
- 3Department of Surgery, Chonnam National University Medical School and Hospital, Gwangju, Korea
- 4Departments of Emergency Medicine, Chonnam National University Medical School, Gwangju, Korea
- 5Departments of Cardiology, Chonnam National University Medical School, Gwangju, Korea
- KMID: 2542946
- DOI: http://doi.org/10.9758/cpn.2023.21.2.386
Abstract
Objective
We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).
Methods
Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.
Results
Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.
Conclusion
By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
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