Acute Crit Care.  2022 Nov;37(4):674-677. 10.4266/acc.2022.01088.

Meta-analysis assessing the effectiveness of intravenous vitamin C in patients with sepsis and septic shock

Affiliations
  • 1Department of Medicine, Dow University Hospital, Dow International Medical College, Karachi, Pakistan
  • 2Ruth KM Pfau Civil Hospital, Dow University of Health Sciences, Karachi, Pakistan


Figure

  • Figure 1. Forest plot showing the effect of intravenous vitamin C compared with control on (A) intensive care unit (ICU) mortality, (B) 30-day mortality, (C) 90-day mortality, and (D) change in Sequential Organ Failure Assessment (SOFA) score at 72 hours. Vit: vitamin; MH: Mantel-Haenszel; CI: confidence interval; HAT: hydrocortisone, ascorbic acid, and thiamine. A list of articles indicated in Figure 1 can be found in the online Supplementary Table 1.


Reference

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3. Sato R, Hasegawa D, Prasitlumkum N, Ueoka M, Nishida K, Takahashi K, et al. Effect of IV high-dose vitamin C on mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med. 2021; 49:2121–30.
4. Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, et al. Intravenous vitamin C in adults with sepsis in the intensive care unit. N Engl J Med. 2022; 386:2387–98.
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5. Agarwal A, Basmaji J, Fernando SM, Ge FG, Xiao Y, Faisal H, et al. Parenteral vitamin C in patients with severe infection: a systematic review. NEJM Evid. 2022; 1.
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