Korean J Otorhinolaryngol-Head Neck Surg.
2023 Feb;66(2):75-84. 10.3342/kjorl-hns.2022.01270.
Effects of Particulate Matter on Allergic Rhinitis and Possible Mechanisms
- Affiliations
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- 1Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea
- 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2539998
- DOI: http://doi.org/10.3342/kjorl-hns.2022.01270
Abstract
- Health impacts of particulate matter (PM) have become a global concern. PM tends to affect patients with allergic diseases, such as allergic rhinitis (AR), more severely. Many epidemiological studies have shown that PM increases outpatient clinic visits as well as the prevalence and severity of AR, while decreasing the quality of life of AR patients. However, the exact mechanisms underlying the effects of PM on the development and exacerbation of AR are still poorly understood. Various mechanisms are involved in the effects of PM on AR, including immunological response, oxidative stress, epithelial barrier dysfunction, allergic sensitization, and epigenetic modification. This article reviews epidemiological and clinical studies on the effects of PM on AR, and the mechanisms by which PM aggravates AR.
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