J Korean Med Sci.  2022 Nov;37(45):e332. 10.3346/jkms.2022.37.e332.

Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies

• Han M
• Oh Y
• Myung SK

• KMID: 2536132
• DOI: http://doi.org/10.3346/jkms.2022.37.e332

Abstract

Background
It remains unclear whether coffee intake is associated with the risk of hypertension. This study aimed to investigate the association between coffee intake and the risk of hypertension by using a meta-analysis of cohort studies.
Methods
PubMed and Embase were searched using keywords in September 2022 to identify studies on coffee intake and the risk of hypertension.
Results
We included a total of 13 longitudinal cohort studies, which involved a total of 64,650 incident cases of hypertension among 314,827 participants. In a random effects model meta-analysis of all the studies, coffee intake was not significantly associated with the risk of hypertension (relative risk [RR], 0.97; 95% confidence interval [CI], 0.90–1.05; I² = 58.0%; n = 13). In the subgroup meta-analysis, coffee intake was associated with a decreased risk of hypertension in studies conducted in America (RR, 0.93; 95% CI, 0.87–0.98; I 2 = 4.6%; n = 5) and in low-quality studies (RR, 0.92; 95% CI, 0.88–0.96; I² = 0.0%; n = 7). In the remaining subgroup meta-analyses by amount of coffee intake, gender, type of coffee (decaffeinated vs. caffeinated), smoking, and years of follow-up, coffee intake was not significantly associated with the risk of hypertension.
Conclusion
The current meta-analysis showed that coffee intake is not associated with the risk of hypertension.

Figure

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  Fig. 1 Flow diagram of identification of relevant studies.

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  Fig. 2 Association between coffee intake and risk of hypertension in a random-effects model meta-analysis of cohort studies (n = 13).RR = relative risk, CI = confidence interval, NHS = nurses’ health study.

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  Fig. 3 Begg’s funnel plots and Egger’s test for identifying publication bias in the meta-analysis of observational studies.RR = relative risk, SE = standard error.

Reference

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005; 365(9455):217–223. PMID: 15652604.

2. He J, Whelton PK. Epidemiology and prevention of hypertension. Med Clin North Am. 1997; 81(5):1077–1097. PMID: 9308599.

3. Jones DW. Dietary sodium and blood pressure. Hypertension. 2004; 43(5):932–935. PMID: 15128720.

4. Geleijnse JM, Kok FJ, Grobbee DE. Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. Eur J Public Health. 2004; 14(3):235–239. PMID: 15369026.

5. Baylin A, Hernandez-Diaz S, Kabagambe EK, Siles X, Campos H. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology. 2006; 17(5):506–511. PMID: 16837823.

6. Godos J, Pluchinotta FR, Marventano S, Buscemi S, Li Volti G, Galvano F, et al. Coffee components and cardiovascular risk: beneficial and detrimental effects. Int J Food Sci Nutr. 2014; 65(8):925–936. PMID: 25046596.

7. Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, et al. Effects of acute administration of caffeine on vascular function. Am J Cardiol. 2006; 98(11):1538–1541. PMID: 17126666.

8. Suzuki A, Yamamoto N, Jokura H, Yamamoto M, Fujii A, Tokimitsu I, et al. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens. 2006; 24(6):1065–1073. PMID: 16685206.

9. Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens. 2006; 28(5):439–449. PMID: 16820341.

10. Zhao Y, Wang J, Ballevre O, Luo H, Zhang W. Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens Res. 2012; 35(4):370–374. PMID: 22072103.

11. Olthof MR, Hollman PC, Buijsman MN, van Amelsvoort JM, Katan MB. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr. 2003; 133(6):1806–1814. PMID: 12771321.

12. Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito I. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertens Res. 2002; 25(1):99–107. PMID: 11924733.

13. Jee SH, He J, Whelton PK, Suh I, Klag MJ. The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials. Hypertension. 1999; 33(2):647–652. PMID: 10024321.

14. Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005; 23(5):921–928. PMID: 15834273.

15. Klag MJ, Wang NY, Meoni LA, Brancati FL, Cooper LA, Liang KY, et al. Coffee intake and risk of hypertension: the Johns Hopkins precursors study. Arch Intern Med. 2002; 162(6):657–662. PMID: 11911719.

16. Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA. 2005; 294(18):2330–2335. PMID: 16278361.

17. Hu G, Jousilahti P, Nissinen A, Bidel S, Antikainen R, Tuomilehto J. Coffee consumption and the incidence of antihypertensive drug treatment in Finnish men and women. Am J Clin Nutr. 2007; 86(2):457–464. PMID: 17684219.

18. Palatini P, Dorigatti F, Santonastaso M, Cozzio S, Biasion T, Garavelli G, et al. Association between coffee consumption and risk of hypertension. Ann Med. 2007; 39(7):545–553. PMID: 17968701.

19. Uiterwaal CS, Verschuren WM, Bueno-de-Mesquita HB, Ocké M, Geleijnse JM, Boshuizen HC, et al. Coffee intake and incidence of hypertension. Am J Clin Nutr. 2007; 85(3):718–723. PMID: 17344492.

20. Grosso G, Stepaniak U, Polak M, Micek A, Topor-Madry R, Stefler D, et al. Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study. Eur J Clin Nutr. 2016; 70(1):109–115. PMID: 26220566.

21. Palatini P, Fania C, Mos L, Garavelli G, Mazzer A, Cozzio S, et al. Coffee consumption and risk of cardiovascular events in hypertensive patients. Results from the HARVEST. Int J Cardiol. 2016; 212:131–137. PMID: 27038718.

22. Rhee JJ, Qin F, Hedlin HK, Chang TI, Bird CE, Zaslavsky O, et al. Coffee and caffeine consumption and the risk of hypertension in postmenopausal women. Am J Clin Nutr. 2016; 103(1):210–217. PMID: 26657046.

23. Chei CL, Loh JK, Soh A, Yuan JM, Koh WP. Coffee, tea, caffeine, and risk of hypertension: the Singapore Chinese Health Study. Eur J Nutr. 2018; 57(4):1333–1342. PMID: 28251341.

24. Navarro AM, Martinez-Gonzalez MA, Gea A, Ramallal R, Ruiz-Canela M, Toledo E. Coffee consumption and risk of hypertension in the SUN Project. Clin Nutr. 2019; 38(1):389–397. PMID: 29331442.

25. Miranda AM, Goulart AC, Benseñor IM, Lotufo PA, Marchioni DM. Coffee consumption and risk of hypertension: a prospective analysis in the cohort study. Clin Nutr. 2021; 40(2):542–549. PMID: 32576389.

26. Tan LJ, Jeon HJ, Park S, Kim SA, Lim K, Chung S, et al. Association of coffee consumption and its types according to addition of sugar and creamer with metabolic syndrome incidence in a Korean population from the health examinees (HEXA) study. Nutrients. 2021; 13(3):1–13.

27. Zhang Z, Hu G, Caballero B, Appel L, Chen L. Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr. 2011; 93(6):1212–1219. PMID: 21450934.

28. Steffen M, Kuhle C, Hensrud D, Erwin PJ, Murad MH. The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J Hypertens. 2012; 30(12):2245–2254. PMID: 23032138.

29. Xie C, Cui L, Zhu J, Wang K, Sun N, Sun C. Coffee consumption and risk of hypertension: a systematic review and dose-response meta-analysis of cohort studies. J Hum Hypertens. 2018; 32(2):83–93. PMID: 29302055.

30. D’Elia L, La Fata E, Galletti F, Scalfi L, Strazzullo P. Coffee consumption and risk of hypertension: a dose-response meta-analysis of prospective studies. Eur J Nutr. 2019; 58(1):271–280. PMID: 29222637.

31. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Non-randomised Studies in Meta-Analyses. Updated 2021. Accessed September 9, 2022. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm .

32. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539–1558. PMID: 12111919.

33. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177–188. PMID: 3802833.

34. Myers MG. Effects of caffeine on blood pressure. Arch Intern Med. 1988; 148(5):1189–1193. PMID: 3284502.

35. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr. 1999; 53(11):831–839. PMID: 10556993.

36. Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res. 2004; 27(10):731–737. PMID: 15785008.

37. Prabha PS, Das UN, Koratkar R, Sagar PS, Ramesh G. Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled essential hypertension. Prostaglandins Leukot Essent Fatty Acids. 1990; 41(1):27–33. PMID: 2174565.

38. Thomas GD, Zhang W, Victor RG. Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension. JAMA. 2001; 285(16):2055–2057. PMID: 11311074.

39. Calver A, Collier J, Moncada S, Vallance P. Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens. 1992; 10(9):1025–1031. PMID: 1328361.

40. Higdon JV, Frei B. Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr. 2006; 46(2):101–123. PMID: 16507475.

41. Shi J, Benowitz NL, Denaro CP, Sheiner LB. Pharmacokinetic-pharmacodynamic modeling of caffeine: tolerance to pressor effects. Clin Pharmacol Ther. 1993; 53(1):6–14. PMID: 8422743.

42. Nussberger J, Mooser V, Maridor G, Juillerat L, Waeber B, Brunner HR. Caffeine-induced diuresis and atrial natriuretic peptides. J Cardiovasc Pharmacol. 1990; 15(5):685–691. PMID: 1692926.