J Korean Neurol Assoc.  2022 Oct;40(4):296-306. 10.17340/jkna.2022.4.2.

Public Action for Prevention of Iatrogenic Transmission Of CJD

• Yang Y
• Kwak YT

• KMID: 2535868
• DOI: http://doi.org/10.17340/jkna.2022.4.2

Abstract

Creutzfeldt-Jakob Disease (CJD) is a rare and a rapidly progressive, invariably fatal neurodegenerative disorder believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. The disease develops in very different ways, such as sporadic, familial, and iatrogenic. Although there is no means to prevent sporadic and familial CJD outbreaks, iatrogenic CJD can be prevented since the iatrogenic transmission pathway to human is mostly identified. However, despite its public health importance, there is no practical laboratory method for diagnosing this disease in an asymptomatic state. Therefore, it is very important to track the infection route one by one and act public preventive measure. However, there are no manual for prevention of iatrogenic transmission of this disease in Korea. Accordingly, this review summarizes on how to evaluate and act on surgical incidents that occurred in patients with CJD or high-risk patients. However, this is not an easy task for public health management teams as this field continues to require new scientific or specialized clinical knowledge. Therefore, a group or organization of expert panels is needed to manage and make decisions in general. Finally, this review was made with reference to the management regulations of countries with widespread exposure to CJD, including variant CJD. In other words, it is a very conservative and strict safety-oriented guideline. However, since the surveillance of diseases must take into each national medical situation and economic burden, some readjustments are necessary to the situation of the Republic of Korea.

Keyword

Creutzfeldt-Jakob disease; Iatrogenic transmission; Prevention; Public health; Surveillance