Clin Psychopharmacol Neurosci.  2022 Aug;20(3):415-426. 10.9758/cpn.2022.20.3.415.

Alterations of Power Spectral Density in Salience Network during Thought-action Fusion Induction Paradigm in Obsessive-compulsive Disorder

Affiliations
  • 1Department of Psychiatry, Kyungpook National University Chilgok Hospital, Daegu, Korea
  • 2Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea
  • 3Department of Medical and Biological Engineering, Kyungpook National University, Daegu, Korea
  • 4Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea
  • 5Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
  • 6GE Health Korea, Seoul, Korea
  • 7Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 8Department of Radiology, Kyungpook National University Hospital, Daegu, Korea

Abstract


Objective
Recent studies highlighted the triple-network model which illustrated the interactions among three large-scale networks including salience network (SN). The functional magnetic resonance imaging used in this study was designed to investigate the characteristics of three large-scale networks associated with the thought-action fusion (TAF) in patients with obsessive-compulsive disorder (OCD) using power spectral density (PSD) analysis.
Methods
This study included 32 OCD patients and 38 age-matched healthy controls (HC). The TAF task was modified from the experiment of Rassin. PSD from time courses in large-scale networks of each subject was measured to compare between the groups for both TAF and resting state.
Results
In SN, OCD reported lower power in the low-frequency domain of SN compared to HC using the two-sample t test during the TAF task (t = −2.395, p = 0.019) but not in the resting state. The PSD in the low-frequency domain of the SN had a significant negative correlation with state score in the guilty inventory (r = −0.361, p = 0.042) in OCD patients.
Conclusion
This study suggests that OCD patients showed reduced SN power which can be prominent in a certain situation, such as TAF. In addition, the PSD alterations in SN cause difficulty in processing ambiguous emotional cues in social situations, and the difficulty can be connected with a negative feeling (e.g., guilt).

Keyword

Obsessive-compulsive disorder; Power spectral density; Salience network; Triple-network model
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