Ann Clin Neurophysiol.  2022;24(1):26-29. 10.14253/acn.2022.24.1.26.

Lumbosacral polyradiculoneuropathy associated with combination therapy of nivolumab and ipilimumab

  • 1Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea
  • 2Department of Neurology, College of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea


Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for advanced cancers. While ICIs have improved survival in multiple cancers, their increased use is restricted by various immune-related adverse events. In this report we describe a patient with renal cell carcinoma who received a combination of ICIs, nivolumab plus ipilimumab, and who developed lumbosacral polyradiculoneuropathy. Corticosteroid use was an effective treatment for this patient.


Polyradiculoneuropathy; Drug-related side effects; Immune checkpoint inhibitors


  • Fig. 1. Sagittal and axial T2-weighted (A, C) and postcontrast T1-weighted (B, D) magnetic resonance imaging demonstrate thickened and enhanced cauda equina. The enhanced cauda equina is indicated by the arrow (B, D).


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