Tuberc Respir Dis.  1987 Dec;34(4):308-313. 10.4046/trd.1987.34.4.308.

The Effect of Ipratropium Bromide as A Bronchodilator in Chronic Obstructive Pulmonary Disease

• KMID: 2528637
• DOI: http://doi.org/10.4046/trd.1987.34.4.308

Abstract

Ipratropium bromide is a new inhaled bronchodilator with anticholinergic properties. The effect of this compound (40 ug) was compared to Fenoterol (400 ug) with beta-adrenergic properties and to combination of 2 drugs in 14 patients with COPD. The drugs were administered by metered dose inhaler, after which FFV _1.0 was checked at time interval of 15 min, 30 min, 60 min, and 90 min. We investigated the bronchodilating effect (FEV₁/ Baseline FEV₁ ) and side effects of each cases and the results were summarized as followings; 1) The bronchodilating effect with the aerosol of Fenoterol was the increment of 11.1± 7.6% in 15 min, 14.2± 6.0% in 30 min, 15.4± 8.6% in 60 min, and 15.1±10.8%in 90 min and showed the maximal effect at the time of 60 minute. In contrast, the bronchodilating effect with the aerosol of Ipratropium bromide was the increment of 13.4± 7.6% in 15 min 19.4± 11.3% in 30 min, 20.6± 10.1 % in 60 min, and 22.9 ± 9.6% in 90 min and showed the maximal effect at the time of 90 min. 2) The bronchodilating effect of Ipratorpium bromide was more pronounced than that of Fenoterol (p < 0.05). 3) The bronchodilating effect in the combination of two drugs, was., the increment of 16.9± 11.0% in 15min, 21.3±11.1% in 30min, 24.3±13.4% in 60min, and 29.7±12.8% in 90min and showed the maximal effect at the time of 90 min. There was the incremental tendency of the bronchodilating effect as the time-course and the additive effects of 2 drugs was observed. 4) The side effects of inhaled Ipratropium bromid were nausea, dry mouth, and throat irritation but not the degree to discontinue the medication. 5) We concluded that Ipratropium bromide is an effective and safe bronchodilator in patients with COPD and its bronchodilating effect is appeared to be slower but more potent than Fenoterol.