Tuberc Respir Dis.  1989 Mar;36(1):47-52. 10.4046/trd.1989.36.1.47.

Circardian Variations of the Peripheral Blood Eosinophil Count and Pulmonary Function in the Bronchial Asthmatics

• KMID: 2528574
• DOI: http://doi.org/10.4046/trd.1989.36.1.47

Abstract

Many investigators now believe that eosinophils are major effector cells of tissue damage in asthma, and abnormal lung function is related to the eosinophilia. The correlation between circadian variations of the peripheral eosinophil count and PEFR (peak expiratory flow rate) was observed in 12 patients with bronchial asthma. Circadian variations of the peripheral eosinophil count revealed 4 distinct types; the first showed continuously elevated counts more than 400/ mm³ (3 cases), the second moderately decreased counts during daytime but increased during night (4 cases), the third irregular counts (2 cases), the fourth normal range less than 300/ mm³ (3 cases). No significant relationship between the peripheral eosinophil count and PEFR was detected for the group as a whole. But the correlation between circadian variations of the peripheral eosinophil count and pulmonary function may be affected by a time sequence, therefore we think the further study is needed.