Asian Oncol Nurs.  2022 Mar;22(1):37-45. 10.5388/aon.2022.22.1.37.

The Influence of Anxiety, Uncertainty, and Cancer Coping on the Quality of Life in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

  • 1RN, Kosin University Gospel Hospital, Busan, Korea
  • 2Associate Professor, College of Nursing, Kosin University, Busan, Korea


The purpose of this study was to investigate the influence of anxiety, uncertainty, and cancer coping on the quality of life in breast cancer patients receiving neoadjuvant chemotherapy.
The participants of the study were 103 breast cancer patients who were in B Metropolitan City. Data had been collected between August 28 and November 22, 2020. For data analysis, SPSS/WIN 24.0 program was used, and descriptive, independent t-test, ANOVA and Scheffe’s test, and Pearson’s correlation coefficients and multiple regression were used for analysis.
The most influencing factor on quality of life was anxiety (β=-.66, p<.001) which was followed by the number of chemotherapy treatments (β=.23, p<.001), interpersonal cancer coping(β=.18, p=.007) and inter-personal cancer coping (β=.18, p=.004). The overall explanatory power was 78.0%.
In order to improve the quality of life for breast cancer patients receiving neoadjuvant chemotherapy, it is necessary to develop a nursing program that may reduce their anxiety, promote cancer coping, and consider the number of their chemotherapy treatments.


Neoadjuvant chemotherapy; Anxiety; Uncertainty; Quality of life; Breast cancer
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