J Pathol Transl Med.  2022 Mar;56(2):103-108. 10.4132/jptm.2021.10.29.

Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review

• Rabie A
• Hasan A
• Mohammed Y
• Abdelmaksoud A
• Rabaan AA

• KMID: 2527195
• DOI: http://doi.org/10.4132/jptm.2021.10.29

Abstract

Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin. Cutaneous malignant SFT is an extremely rare tumor that resembles dermatofibrosacoma protuberance (DFSP) histologically and immunohistochemically. Herein, we describe a case of malignant SFT that presented as a recurrent mass on the scalp. The first lesion was totally excised one year before recurrence and was diagnosed as a DFSP based on the histopathology and cluster of differentiation 34 immunostaining positivity. Re-examination of the previously examined specimen was considered. Activator of transcription 6 positivity was also detected in the tissue, confirming the diagnosis of a recurrent malignant SFT rather than DFSP. There was no evidence of recurrence, locoregional, or distant metastases at six months after lesion removal with a safety margin.

Keyword

Solitary fibrous tumor; Skin cancer; Immunohistochemistry

Figure

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  Fig. 1 A gross picture showing ulcerated skin (A) and fairly defined lobulated whitish mass with central focal necrosis (B).

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  Fig. 2 A histopathology picture showing a cellular spindle cell tumor arranged in irregular short bundles with staghorn blood vessels (A) and mitotic figures (circles) (B).

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  Fig. 3 Immunohistochemical staining. (A) The STAT6 result is positive (diffuse nuclear staining). (B) The CD34 finding is positive (cytoplasmic staining).

Reference

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