J Korean Soc Matern Child Health.  2022 Jan;26(1):27-34. 10.21896/jksmch.2022.26.1.27.

Clinical Features of Group B Streptococcus Colonization in Vagina During Late Pregnancy at a Primary Maternity Hospital

• Oh S
• Park JS

• KMID: 2525369
• DOI: http://doi.org/10.21896/jksmch.2022.26.1.27

Abstract

Purpose
The aim of this study was to assess the epidemiologic and clinical features of maternal Group B Streptococcus (GBS) colonization in vagina during their third trimester.
Methods
This study included 644 pregnant women who had undergone GBS culture test in their third trimester in 2018. We collected data from the primary level of care maternity hospital through the retrospective chart review. We compared patients’ demographics, maternal obstetrical complications and neonatal adverse events between GBS positive (n=41) and GBS negative (n=603) groups. To find out clinical predictors of GBS positive result, univariable chi-square test and multivariable logistic regression analysis were applied.
Results
The colonization rate of GBS in maternal vagina was 6.4% in their third trimester. GBS positive group showed significant association with the third trimester anemia (hemoglobin level <10.5 g/dL) (p=0.013) and oligohydramnios (p=0.024; odds ratio, 7.32; 95% confidence interval, 1.28–41.31). All specimens were susceptible to penicillin G and cephalosporin. The antibiotic resistance to both erythromycin and clindamycin was 31%.
Conclusion
The colonization rate of GBS in maternal vagina was 6.4% and third trimester maternal anemia was associated with the GBS carrying status.

Keyword

Anemia, Antibiotic resistance, Colonization, Group B Streptococcus, Third pregnancy trimester

Figure

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  Fig. 1. Group B Streptococcus (GBS) colonization rate at the index primary maternity hospital between 2015 and 2018. The rate did not show a difference by year (p=0.494).

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