Nucl Med Mol Imaging.  2021 Dec;55(6):320-322. 10.1007/s13139-021-00724-4.

Incidental Muscle Uptake of  177 Lu-DOTATATE in Peripheral Vascular Disease

  • 1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
  • 2Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India


Somatostatin receptor (SSTR)-based imaging and therapy has emerged as well-established modality in neuroendocrine tumors. However, its role in inflammation imaging is still evolving. We present a 48-year-old male with metastatic neuroendocrine tumor who underwent lutetium-177-based somatostatin receptor-based therapy. The post-therapy scan showed a focal tracer uptake in the left calf muscle in addition to the expected tracer uptake at the primary and metastatic sites. Further, cross-sectional imaging and biochemical investigations revealed peripheral vascular disease (PVD). The incidental tracer uptake in the calf on post-therapy scan potentiates the role of somatostatin receptor scintigraphy in identifying macrophagespecific inflammatory reactions.


Lutetium-177; DOTATATE; Neuroendocrine tumors; Peripheral vascular diseases
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