Korean J Med.  2021 Dec;96(6):450-454. 10.3904/kjm.2021.96.6.450.

Heterologous Vaccination for Preparing COVID-19 Pandemic

• Kim TH

• KMID: 2523026
• DOI: http://doi.org/10.3904/kjm.2021.96.6.450

Abstract

Infectious disease pandemics are characterized by extreme uncertainty. From the more predictable response to seasonal influenza, which occurs each year, we have learned the importance of effective universal vaccines and therapeutic agents to protect high-risk groups. Heterologous vaccination with different types of vaccines to prevent COVID-19 is already recommended for various reasons: shortages of mass vaccine supply; critical adverse events, and potential superior efficacy as a booster dose. However, very few studies have examined the efficacy and safety of heterologous vaccination with mixed types. This review discusses the efficacy of vaccines currently approved in the Republic of Korea, including heterologous vaccination options.

Keyword

COVID-19; Vaccines; Heterologous vaccination