Neonatal Med.  2021 Nov;28(4):153-156. 10.5385/nm.2021.28.4.153.

Human Herpesvirus 6 Meningitis in a Neonatal Case

Affiliations
  • 1Department of Pediatrics, Kosin University College of Medicine, Busan, Korea

Abstract

Incidence of human herpesvirus-6 (HHV-6) infection in the neonatal period has been reported in few cases. HHV-6, commonly responsible for roseola, is known to establish infection during infancy and early childhood. A 14-day-old neonate, presented with a fever of 38.3℃, primarily due to an HHV-6 infection, was admitted to our neonatal intensive care unit. A polymerase chain reaction (PCR) of his cerebrospinal fluid was positive for HHV-6. Additionally, serology for HHV-6 PCR was positive. We believe that HHV-6 can cause infection in febrile newborn infants.

Keyword

Herpesvirus 6, human; Meningitis; Infant, newborn

Figure

  • Figure 1. Hospital course of patient. Abbreviations: HD, hospital day; HS-CRP, high sensitivity C-reactive protein; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging; PCR, polymerase chain reaction; HHV-6, human herpesvirus-6.


Reference

1. Tesini BL, Caserta MT. Roseola (human herpesviruses 6 and 7). In : Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson textbook of pediatrics. 21st ed. Philadelphia (PA): Elsevier;2020. p. 1723–6.
2. Kim F, Reichman V, Hooven TA. Human herpesvirus-6 meningitis in a premature infant with fevers: a case and literature review. Clin Med Insights Case Rep. 2020; 13:1179547620912952.
3. Byington CL, Zerr DM, Taggart EW, Nguy L, Hillyard DR, Carroll KC, et al. Human herpesvirus 6 infection in febrile infants ninety days of age and younger. Pediatr Infect Dis J. 2002; 21:996–9.
4. Ohashi M, Ihira M, Suzuki K, Suga S, Asano Y, Yoshikawa T, et al. Transfer of human herpesvirus 6 and 7 antibodies from mothers to their offspring. Pediatr Infect Dis J. 2001; 20:449–50.
5. Tanaka-Taya K, Kondo T, Mukai T, Miyoshi H, Yamamoto Y, Okada S, et al. Seroepidemiological study of human herpesvirus-6 and -7 in children of different ages and detection of these two viruses in throat swabs by polymerase chain reaction. J Med Virol. 1996; 48:88–94.
6. Tesini BL, Epstein LG, Caserta MT. Clinical impact of primary infection with roseoloviruses. Curr Opin Virol. 2014; 9:91–6.
7. Baillargeon J, Piper J, Leach CT. Epidemiology of human herpesvirus 6 (HHV-6) infection in pregnant and nonpregnant women. J Clin Virol. 2000; 16:149–57.
8. Sugimoto T, Tanaka-Taya K, Ono J, Miyoshi H, Okada S, Yamanishi K. Human herpesvirus-6 infection in neonates: not protected by only humoral immunity. Pediatr Int. 2002; 44:281–5.
9. Brown NA, Sumaya CV, Liu CR, Ench Y, Kovacs A, Coronesi M, et al. Fall in human herpesvirus 6 seropositivity with age. Lancet. 1988; 2:396.
10. Ranger S, Patillaud S, Denis F, Himmich A, Sangare A, M’Boup S, et al. Seroepidemiology of human herpesvirus-6 in pregnant women from different parts of the world. J Med Virol. 1991; 34:194–8.
11. Lee R, Hur JK, Kim JH, Shin WS, Choi JH, Han H, et al. Seroepidemiology and typing of human herpesvirus 6 in healthy Korean children. Korean J Infect Dis. 2000; 32:415–22.
12. Yao K, Crawford JR, Komaroff AL, Ablashi DV, Jacobson S. Review part 2: human herpesvirus-6 in central nervous system diseases. J Med Virol. 2010; 82:1669–78.
13. Sugaya N, Yoshikawa T, Miura M, Ishizuka T, Kawakami C, Asano Y. Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. Clin Infect Dis. 2002; 34:461–6.
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