Korean J Otorhinolaryngol-Head Neck Surg.
2021 Oct;64(10):760-765. 10.3342/kjorl-hns.2020.00703.
Anaplastic Lymphoma Kinase Positive Large B-cell Lymphoma Mimicking Metastatic Carcinoma of the Cervical Lymph Node from an Unknown Primary Lesion
- Affiliations
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- 1Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea
- 2Department of Pathology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea
- 3Sensory Organ Research Institute, College of Medicine, Dongguk University, Gyeongju, Korea
- KMID: 2521701
- DOI: http://doi.org/10.3342/kjorl-hns.2020.00703
Abstract
- Anaplastic lymphoma kinase positive large B-cell lymphoma (ALK+LBCL) is a rare subtype of B-cell lymphoma with aggressive features and a poor prognosis. The rarity of this disease and similarity of microscopic features with undifferentiated epithelial neoplasm disturb the provision of proper treatment. A 57-year-old male presented with a rapidly growing and painless mass on the left side of the neck. Metastatic carcinoma of an unknown primary (CUP) lesion was initially suspected based on the pathologic results obtained from a core needle biopsy, but it was finally diagnosed as ALK+LBCL after a modified radical neck dissection. We herein report a case of ALK+LBCL mimicking CUP with a literature review.
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