Pediatr Gastroenterol Hepatol Nutr.  2021 Jul;24(4):403-412. 10.5223/pghn.2021.24.4.403.

Vitamin D Status of Breastfed Filipino Infants Aged Less Than 6 Months in an Urban Community

• los Angeles EPd
• Retoriano K
• Arnaldo H
• Ronquillo-Nolasco ME
• Urtula R

• KMID: 2518440
• DOI: http://doi.org/10.5223/pghn.2021.24.4.403

Abstract

Purpose
This study aimed to determine the serum 25-hydroxy-vitamin D (25(OH)D) status of breastfed infants less than six months old and their mothers, and factors affecting the status.
Methods
This cross-sectional study was done on breastfed, term, Filipino infants less than six months old who were seen at local health centers and clinics in an urban area. The serum 25(OH)D levels of these infants and their mothers were determined, and their demographic data, nutritional status, sun exposure behavior, and maternal vitamin D intake were analyzed for correlation using regression models.
Results
Among the 131 infants, 101 (77%) had vitamin D deficiency (VDD), which was defined as having 25(OH)D levels <37.5 nmol/L, and 13 (10%) had vitamin D insufficiency (VDI), with levels >37.5–50 nmol/L. Conversely, maternal VDD with levels <50 nmol/L was seen in 31 (24%) mothers and maternal VDI with levels 50–75 nmol/L, in 63 (48%) mothers. Infant age and maternal 25(OH)D status were independent predictors of infant VDD. Infants less than three months old were found to have a six-time increased risk of infant VDD (p=0.004). Infants who had mothers with VDD had a six-time increased risk, whereas those with maternal VDI had a four-time increased risk of infant VDD (p=0.049 and p=0.020, respectively).
Conclusion
Both infant and maternal VDD and VDI were seen to be highly prevalent in this tropical, urban community. Young infants and maternal VDD/VDI independently increased the risk of infant VDD, whereas lack of sun exposure of the mothers increased the risk for maternal VDI. Keyw

Keyword

Vitamin D deficiency; Infant; Mothers; Breast feeding; Philippines