Ann Clin Microbiol.  2021 Mar;24(1):11-20. 10.5145/ACM.2021.24.1.2.

Risk Factors Associated with Recurrent Urinary Tract Infection Caused by Escherichia coli

Affiliations
  • 1Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
  • 2Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
  • 3Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea
  • 4Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea

Abstract

Background
The purpose of this study was to analyze the clinical and microbiological characteristics of recurrent urinary tract infection (UTI) caused by Escherichia coli— the most common etiological agent.
Methods
Cases of recurrent and single episodes of UTI caused by E. coli were evaluated retrospectively for a period of 6 months (January-June 2019) to analyze the clinical and molecular characteristics of this disease.
Results
Healthcare-associated UTI, E. coli bacteremia, and poor microbial clearance 7 days post infection were associated more with the recurrent episodes of infection. E. coli isolates from subjects with recurrent UTIs showed higher rates of antimicrobial resistance and extended-spectrum β-lactamase (ESBL) production. The E. coli clone— sequence type 131 was detected in similar proportions in isolates, recovered from subjects in both groups— recurrent episodes and single episode of UTI.
Conclusion
The control of antimicrobial-resistant ESBL-producing E. coli strains may be difficult using antimicrobial therapy and subsequently delay the clearance of the etiologic agent. This could play a major role in the development of recurrent UTIs.

Keyword

Escherichia coli; Extended-spectrum β-lactamases; Recurrent urinary tract infection; Risk factors; Sequence type 131
Full Text Links
  • ACM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error