Korean J Dermatol.  2021 Feb;59(2):157-159.

A Case of Cytophagic Histiocytic Panniculitis Associated with Hemophagocytic Lymphohistiocytosis

Affiliations
  • 1Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea
  • 2Department of Laboratory Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea

Abstract

Cytophagic histiocytic panniculitis (CHP) is a rare form of panniculitis, presenting lymphohistiocytic infiltration within subcutaneous fat tissue with phagocytic histiocytes. Associated systemic symptoms includes fever, hepatosplenomegaly, lymphadenopathy, serositis, pancytopenia, hepatic abnormalities, hypertriglyceridemia, and coagulopathy, which are the features of hemophagocytic lymphohistiocytosis (HLH). The patients of CHP associated with HLH may have nonfatal acute/intermittent, or rapidly fatal clinical courses, so the prompt and accurate diagnosis with immunosuppressive treatments are significant.

Keyword

Cytophagic histiocytic panniculitis; Hemophagocytic lymphohistiocytosis; Macrophage activation syndrome; Subcutaneous panniculitis-like T cell lymphoma
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