Korean J Radiol.  2021 Mar;22(3):405-414. 10.3348/kjr.2020.0518.

Clinically Available Software for Automatic Brain Volumetry: Comparisons of Volume Measurements and Validation of Intermethod Reliability

Affiliations
  • 1Department of Radiology, Hanyang University Medical Center, Seoul, Korea
  • 2Department of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 3Department of Radiology, Chung-Ang University Hospital, Seoul, Korea
  • 4Department of Radiology, Asan Medical Center, Seoul, Korea
  • 5Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
  • 6Department of Psychiatry, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
  • 7Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea

Abstract


Objective
To compare two clinically available MR volumetry software, NeuroQuant® (NQ) and Inbrain® (IB), and examine the inter-method reliabilities and differences between them.
Materials and Methods
This study included 172 subjects (age range, 55–88 years; mean age, 71.2 years), comprising 45 normal healthy subjects, 85 patients with mild cognitive impairment, and 42 patients with Alzheimer’s disease. Magnetic resonance imaging scans were analyzed with IB and NQ. Mean differences were compared with the paired t test. Inter-method reliability was evaluated with Pearson’s correlation coefficients and intraclass correlation coefficients (ICCs). Effect sizes were also obtained to document the standardized mean differences.
Results
The paired t test showed significant volume differences in most regions except for the amygdala between the two methods. Nevertheless, inter-method measurements between IB and NQ showed good to excellent reliability (0.72 < r < 0.96, 0.83 < ICC < 0.98) except for the pallidum, which showed poor reliability (left: r = 0.03, ICC = 0.06; right: r = -0.05, ICC = -0.09). For the measurements of effect size, volume differences were large in most regions (0.05 < r < 6.15). The effect size was the largest in the pallidum and smallest in the cerebellum.
Conclusion
Comparisons between IB and NQ showed significantly different volume measurements with large effect sizes. However, they showed good to excellent inter-method reliability in volumetric measurements for all brain regions, with the exception of the pallidum. Clinicians using these commercial software should take into consideration that different volume measurements could be obtained depending on the software used.

Keyword

MRI; Alzheimer’s disease; Softwares; Brain volumetry; NeuroQuant®; Reliability
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