Tissue Eng Regen Med.  2021 Feb;18(1):113-125. 10.1007/s13770-020-00322-z.

Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Affiliations
  • 1Department of Orthopedics, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650035, People’s Republic of China
  • 2Department of Maternity, The Second Affiliated Hospital of Kunming Medical University, Kunming 650051, People’s Republic of China
  • 3Department of Gastroenterology, Chenggong Hospital, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650035, People’s Republic of China
  • 4Department of Orthopedics, Chenggong Hospital, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650035, People’s Republic of China
  • 5Department of Cardiology, Chenggong Hospital, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650035, People’s Republic of China

Abstract

BACKGROUND
Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of longterm maintenance of efficacy.
METHODS
In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N-carboxyethyl chitosan (N-chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid–aldehyde (HA-ALD).
RESULTS
This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-a, IL-1b, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection.
CONCLUSION
This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.

Keyword

Chitosan; Hyaluronic acid; Hydrogel; Osteoarthritis; Intra-articular injection
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