Genomics Inform.  2020 Dec;18(4):e36. 10.5808/GI.2020.18.4.e36.

The ceRNA network of lncRNA and miRNA in lung cancer

Affiliations
  • 1Department of Science Education, Korea National University of Education, Cheongju 28173, Korea
  • 2Department of Science Education, Chungbuk Science High School, Cheongju 28189, Korea
  • 3Department of Biology Education, Korea National University of Education, Cheongju 28173, Korea

Abstract

Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are being exponentially studied as promising biomarkers of lung cancer. Moreover, supportive evidence provides the competing endogenous RNA (ceRNA) network between lncRNAs and miRNAs participating in lung tumorigenesis. This review introduced the oncogenic or tumor-suppressive roles of lncRNAs and miRNAs in lung cancer cells and summarized the involvement of the lncRNA/miRNA ceRNA networks in carcinogenesis and therapeutic resistance of lung cancer.

Keyword

competing endogenous RNA; long non-coding RNA; miRNA; lung tumorigenesis; therapeutic resistance
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