Kosin Med J.  2020 Dec;35(2):114-124. 10.7180/kmj.2020.35.2.114.

Differences in Endoscopic Findings of Primary and Secondary Gastric Lymphoma

  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea


Since endoscopic findings of primary gastric lymphoma are ambiguous and diverse, it is not easy to distinguish them from gastric adenocarcinoma or secondary gastric lymphoma. The aim of this study was to investigate the difference in clinical and endoscopic features between primary gastric lymphoma and gastric involvement of lymphoma.
Forty-eight patients were enrolled in this retrospective study between June 2008 and February 2017. The patients were divided into primary gastric lymphoma group (primary group, n = 18) and gastric involvement group (secondary group, n = 30) based on whether or not they carried gastric lesions alone. Patients’ clinical characteristics, endoscopic findings and pathologic data were retrospectively reviewed based on electronic medical records.
The mean age of patients was 63.3 ± 13.1 years and 29 patients were female (60.4%). Diffuse large B-cell lymphoma pathology (81.3%), gastric body involvement (47.9%) and ulceroinfiltrative morphology on endoscopy (43.8%) were common features. Regardless of the two groups, the initial endoscopic diagnosis was considered as lymphoma only in 41.7%. Compared with the primary group, fundus (P = 0.035) and regional lymph node (P < 0.001) were significantly associated with the secondary group. However, there was no significant difference in endoscopic findings including location, size, number, and morphology of lesion.
Endoscopic diagnosis of gastric lymphoma is a challenge. There is no difference in endoscopic findings between the primary and secondary groups even when confirmed separately. However, when the lesion is present in the fundus, we keep in mind the possibility of secondary gastric lymphoma.


Endoscopy; Lymphoma; Stomach neoplasm


  • Fig. 1 Flow chart of patients (Abbreviation. GL, gastric lymphoma).

  • Fig. 2 Endoscopic classification for gastric lymphomas

  • Fig. 3 PET-CT features of endoscopically polypoid mass-like lesions in primary DLBCL (A) and secondary DLBCL (B) cases (Abbreviation. PET-CT, positron emission tomography-computed tomography; DLBCL, diffuse large B-cell lymphoma).

  • Fig. 4 Endoscopically ulceroinfiltrative lesions of two cases. (A) Primary gastric lymphoma which was diagnosed as mantle-cell lymphoma. (B) Secondary gastric lymphoma which was diagnosed as DLBLC. (C) Multiple involved lymph nodes and organs were observed on PET-CT in same patients of B (Abbreviation. DLBCL, diffuse large B-cell lymphoma; PET-CT, positron emission tomography-computed tomography).

  • Fig. 5 Two cases of mixed type with two or more endoscopic findings. (A) Primary DLBLC. (B) Secondary DLBLC. (C) Hypermetabolism of stomach and multiple distant lymph node was seen on PET-CT in cases of B (Abbreviation. DLBCL, diffuse large B-cell lymphoma; PET-CT, positron emission tomography-computed tomography).


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