World J Mens Health.  2021 Jan;39(1):99-106. 10.5534/wjmh.190121.

Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes

Affiliations
  • 1Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.
  • 2Assisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
  • 3Campania Pharmacovigilance and Pharmacoepidemiology Regional Centre, Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy.
  • 4Department of Gynecology and Obstetrics, St. Claire Hospital, University of Pisa, Pisa, Italy.
  • 5Department of Critical Care Medicine and Surgery, Infectious Disease Unit, Careggi Hospital, University of Florence, Florence, Italy.

Abstract

Purpose
To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes.
Materials and Methods
A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected.
Results
No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs.55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05).
Conclusions
HBV infected men have the same chance to became father, compared to seronegative patients.

Keyword

Anti-hepatitis B antigens; Hepatitis B virus; Infection; Intracytoplasmic sperm injections; In Vitro fertilization; Male infertility
Full Text Links
  • WJMH
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr