J Korean Med Sci.  2020 Dec;35(46):e394. 10.3346/jkms.2020.35.e394.

Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel

• Jin Y
• Cha S
• Lee J
• Elhag MS
• Hong ST
• Lee YH

• KMID: 2509037
• DOI: http://doi.org/10.3346/jkms.2020.35.e394

Abstract

This study compared the anthelminthic effects of three different brands of praziquantel being used in Sudan against Schistosoma haematobium (S. haematobium) infection. We enrolled 1,286 schoolchildren from six primary schools and examined their urine samples for eggs of S. haematobium at the baseline survey and follow-up two weeks after administering the medication. The schoolchildren were divided into three groups based on the three brands of praziquantel (different material production), with two school children for one brand. The overall baseline prevalence of S. haematobium infection was 15.5%. Two weeks after treatment with brands A, B, and C of praziquantel, cure rates were 87.1%, 82.4% and 83.8% respectively, and the egg-reduction rates were 69.0%, 81.0% and 70.6% respectively. There was no statistically significant difference in cure rates and egg-reduction rates between the three brands. We conclude that the three different commercial brands of praziquantel used in Sudan have similar anthelminthic effects on S. haematobium.

Keyword

Schistosoma haematobium; Praziquantel; Anthelminthic Effect; Cure Rate; Egg Reduction Rate; Sudan