J Korean Med Sci.  2020 Nov;35(45):e377. 10.3346/jkms.2020.35.e377.

Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury

Affiliations
  • 1Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
  • 2Department of Occupational and Environmental Medicine, Inha University College of Medicine, Incheon, Korea
  • 3Department of Preventive Medicine, Dong-A University Collage of Medicine, Busan, Korea
  • 4Department of Occupational and Environmental Medicine, Kosin University College of Medicine, Busan, Korea
  • 5Total Health Care Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyungkwan University, Seoul, Korea
  • 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea
  • 7Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea

Abstract

Background
To compare the chest computed tomography (CT) images of children and adults in families with clusters of humidifier disinfectant-related lung injury (HDLI) after cessation of exposure to humidifier disinfectant (HD).
Methods
We reviewed medical records of 19 families with 43 patients (21 adults, 22 children) among families, which had at least one adult and one child with HDLI. Each family was exposed to the same HD exposure environment.
Results
In adults, centrilobular nodules were predominant (95.2%) in chronic HDLI findings after cessation of exposure to HD, however, in children, normal pattern was most prevalent on chest CT (45.5%), followed by centrilobular nodule (36.4%), bizarre lung cysts (36.4%), and reticulation (13.6%).
Conclusion
Unlike the known chronic HDLI finding of adults, centrilobular nodules were only present in 36.4% of children. The frequency of bizarre lung cysts were significantly greater in children than that in adults after cessation of similar exposure to HD. Thus, bizarre lung cysts may be useful as another novel finding of chronic HDLI in children who have no history of pulmonary infection or other perinatal disorder such as hyaline membrane disease or other interstitial lung disease.

Keyword

Humidifier Disinfectant; Lung Injury; Computed Tomography; Lung Cyst; Sequele
Full Text Links
  • JKMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr