J Korean Med Sci.  2020 Nov;35(45):e377. 10.3346/jkms.2020.35.e377.

Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury

  • 1Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
  • 2Department of Occupational and Environmental Medicine, Inha University College of Medicine, Incheon, Korea
  • 3Department of Preventive Medicine, Dong-A University Collage of Medicine, Busan, Korea
  • 4Department of Occupational and Environmental Medicine, Kosin University College of Medicine, Busan, Korea
  • 5Total Health Care Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyungkwan University, Seoul, Korea
  • 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea
  • 7Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea


To compare the chest computed tomography (CT) images of children and adults in families with clusters of humidifier disinfectant-related lung injury (HDLI) after cessation of exposure to humidifier disinfectant (HD).
We reviewed medical records of 19 families with 43 patients (21 adults, 22 children) among families, which had at least one adult and one child with HDLI. Each family was exposed to the same HD exposure environment.
In adults, centrilobular nodules were predominant (95.2%) in chronic HDLI findings after cessation of exposure to HD, however, in children, normal pattern was most prevalent on chest CT (45.5%), followed by centrilobular nodule (36.4%), bizarre lung cysts (36.4%), and reticulation (13.6%).
Unlike the known chronic HDLI finding of adults, centrilobular nodules were only present in 36.4% of children. The frequency of bizarre lung cysts were significantly greater in children than that in adults after cessation of similar exposure to HD. Thus, bizarre lung cysts may be useful as another novel finding of chronic HDLI in children who have no history of pulmonary infection or other perinatal disorder such as hyaline membrane disease or other interstitial lung disease.


Humidifier Disinfectant; Lung Injury; Computed Tomography; Lung Cyst; Sequele
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