J Liver Cancer.  2020 Sep;20(2):177-182. 10.17998/jlc.20.2.177.

Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis

• Jo HH
• Chun SJ
• Yoo JJ
• Lee MH
• Kim SG
• Kim YS

• KMID: 2508031
• DOI: http://doi.org/10.17998/jlc.20.2.177

Abstract

JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.

Keyword

Oncolytic virus; JX-594; Sorafenib

Figure

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  Figure 1 (A) After three sessions of transarterial chemoembolization, the tumor size increased to 5.8 cm in diameter. (B) Tumor thrombus was noted in the middle hepatic vein (arrow).

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  Figure 2 Study week 6 of JX-594 injections. The size of the total tumor increased from 5.8 cm to 7.0 cm in diameter, but the enhancing portion of the tumor decreased.

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  Figure 3 Graph of alpha-fetoprotein (AFP) values throughout the JX-594 trial.

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  Figure 4 (A) Study week 16 of JX-594 injections. The total size of the tumor decreased to 3.7 cm in diameter. There are only a few small arterial enhancing nodules inside the tumor. (B) Study week 30 of JX-594 injections. The size of the enhancing nodules within the necrotic material (arrow) increased. (C) Study week 40 of JX-594 injections. The total tumor size increased to 4.6 cm in diameter. (D) Study week 54 of JX-594 injections. Multiple intrahepatic metastases appeared.

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