Clin Mol Hepatol.
2020 Oct;26(4):705-714. 10.3350/cmh.2020.0166.
Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease
- Affiliations
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- 1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
- 2Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing, China
- 3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
- 4Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA
- KMID: 2507992
- DOI: http://doi.org/10.3350/cmh.2020.0166
Abstract
- Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
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