Psychiatry Investig.  2020 Sep;17(9):925-933. 10.30773/pi.2020.0132.

Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children

Affiliations
  • 1Department of Psychiatry, Woorisoa Children’s Hospital, Seoul, Republic of Korea
  • 2Department of Health Sciences & Technology, Gachon University, Incheon, Republic of Korea
  • 3Department of Child and Adolescent Psychiatry, National Center for Mental Health, Seoul, Republic of Korea
  • 4Department of Psychiatry, Chung-Ang University Hospital, Seoul, Republic of Korea

Abstract


Objective
We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.
Methods
Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.
Results
Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.
Conclusion
We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.

Keyword

Attention-deficit hyperactivity disorder, Dorsal attention network, Default mode network, Catechol-O-methyltransferase
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