J Korean Assoc Oral Maxillofac Surg.  2020 Aug;46(4):220-227. 10.5125/jkaoms.2020.46.4.220.

Oral rehabilitation of Papillon–Lefèvre syndrome patients by dental implants: a systematic review

• Atarbashi-Moghadam F
• Atarbashi-Moghadam S
• Kazemifard S
• Sijanivandi S
• Namdari M

• KMID: 2505433
• DOI: http://doi.org/10.5125/jkaoms.2020.46.4.220

Abstract

Objectives
Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder. These patients lose their teeth at a young age and are in need of prosthetic rehabilitation. The aim of this systematic review was to assess the success of dental implant placement in these patients.
Materials and Methods
An electronic search was performed in PubMed Central, Scopus, and Web of Science using the keyword “Papillon–Lefèvre syndrome” AND “dental implant” OR “prosthodontics”. Articles reporting implant placement in patients with PLS until July 2019 were included.
Results
Assessment of the included 11 articles reporting 15 cases showed 136 implant placements in these patients. Implant failure occurred in 3 patients (20 implants). The peri-implantitis and failure rate was higher in the maxilla. Meta-analysis showed the probability of failure to be 7% (95% confidence interval [CI] 0%-31%) for maxillary implants and 2% (95% CI 0%-9%) for mandibular implants. The follow-up time ranged between 1 and 20 years. Healing after bone graft and implant placement in these patients was uneventful.
Conclusion
Dental implants may be a viable treatment option for PLS patients. Implantation can help preserve alveolar bone if the patients’ immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued.

Keyword

Papillon–Lefèvre syndrome; Dental implants; Oral rehabilitation; Prosthodontics; Rapid progressive periodontitis

Figure

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  Fig. 1 Diagram of literature search and selection criteria adapted from PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 12. (PLS: Papillon–Lefèvre syndrome)

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  Fig. 2 Probability of implant failure based on maxillary and mandibular implant. (ES: effect size, CI: confidence interval)

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