Allergy Asthma Respir Dis.  2020 Jul;8(3):150-154. 10.4168/aard.2020.8.3.150.

A case of diacerein-induced DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome with thromboembolic complications

Affiliations
  • 1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
  • 2Dong-A University Hospital Regional Pharmacovigilance Center, Busan, Korea
  • 3Department of Pathology, Dong-A University College of Medicine, Busan, Korea

Abstract

Diacerein is a safe drug for osteoarthritis due to its inhibitory effect on proinflammatory cytokines. Its common side effects, such as diarrhea, abdominal pain and skin rash, are relatively mild. There have been a few cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome accompanied by thromboembolic complications. We report the first case of diacerein-induced DRESS syndrome with thromboembolic complications. A 64-year-old man developed fever, skin rash, increase in liver enzymes, eosinophilia, deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) after taking diacerein. DVT and PTE were improved after anticoagulation therapy; however, fever, skin rash, eosinophilia and increase in liver enzymes were aggravated. A high-dose systemic corticosteroid (methylprednisolone 1 mg/kg/day) was administered, after which his clinical conditions improved.

Keyword

DRESS syndrome; Drug hypersensitivity; Thromboembolism; Diacerein
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