Ann Child Neurol.  2020 Jul;28(3):76-87. 10.26815/acn.2020.00073.

The Genetic Relationship between Paroxysmal Movement Disorders and Epilepsy

Affiliations
  • 1Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea

Abstract

Seizures and movement disorders both involve abnormal movements and are often difficult to distinguish due to overlapping phenomenology and possible etiological commonalities. Paroxysmal movement disorders, which include three paroxysmal dyskinesias syndromes (paroxysmal kinesigenic dyskinesia, paroxysmal non-kinesigenic dyskinesia, paroxysmal exercise-induced dyskinesia), hemiplegic migraine, and episodic ataxia, are important paradigms where movement disorders and seizures overlap. Recently, many articles describing genes associated with paroxysmal movement disorders and epilepsy have been published, providing much information about their molecular pathology. In this review, we summarize the main genetic disorders generating co-occurrence of epilepsy and paroxysmal movement disorders with gene characteristics, suspected pathomechanisms, and detailed descriptions of paroxysmal movement disorders and seizure types.

Keyword

Dyskinesias; Movement disorders; Seizures; Epilepsy
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