Perinatology.  2020 Jun;31(2):90-93. 10.14734/PN.2020.31.2.90.

Placental Mesenchymal Dysplasia Associated with Placenta Previa and Preterm Labor

  • 1Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital, Seoul Korea
  • 2Departments of Obstetrics and Gynecology, Jeju National University Hospital, Jeju, Korea
  • 3Departments of Pathology, Jeju National University Hospital, Jeju, Korea


Placental mesenchymal dysplasia is a rare placental vascular anomaly characterized by placentomegaly and grape-like vesicles and is recently recognized condition. This resembles partial molar pregnancy by ultrasonography. Placental mesenchymal dysplasia may be associated with adverse complications such as prematurity and intrauterine growth restriction. If placental mesenchymal dysplasia is suspected after antenatal ultrasonography, a serial fetal surveillance should be provided. The placenta should be sent for pathological evaluation after delivery for confirmation of placental mesenchymal dysplasia. A 34 year-old nulliparous woman was referred to Jeju National University Hospital at 24 weeks 3 days of gestation because of preterm vaginal bleeding and multiple cysts in the placenta with previa marginalis by prenatal ultrasonography. At 26 weeks 2 days of gestation, uncontrolled vaginal bleeding and preterm labor ensued, and emergency cesarean section was done. After delivery, histopathologic result of the placenta was placental mesenchymal dysplasia and acute chorioamnionitis. We have described a case complicated with placental mesenchymal dysplasia associated with placenta previa and preterm labor.


Placental mesenchymal dysplasia; Placenta previa; Preterm labor
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