Int J Thyroidol.  2020 May;13(1):13-18. 10.11106/ijt.2020.13.1.13.

Antenatal Thyroid Function Does Not Increase Risk of Gestational Diabetes Mellitus in a Multi-Ethnic Pregnancy Cohort

Affiliations
  • 1Department of Endocrinology, St. Vincent’s Hospital, Division of Medicine
  • 2The Canterbury Hospital, Clinical Research Centre
  • 3Sydney Local Health District, Sydney, NSW, Australia

Abstract

Background and Objectives
Subclinical hypothyroidism in pregnancy has been inconsistently associated with an increased risk of developing gestational diabetes mellitus (GDM).
Materials and Methods
We retrospectively examined whether an antenatal thyroid stimulating hormone (TSH) level ≥2.5 mIU/L was associated with increased risk of GDM in 1147 pregnant women residing in a multi-ethnic suburban area of Sydney, Australia.
Results
Despite a high prevalence of GDM and hypothyroidism in our study, women with antenatal TSH concentrations ≥2.5 mIU/L were not at increased risk for development of gestational diabetes. Traditional risk factors for GDM, such as maternal body mass index, ethnicity, previous GDM pregnancy and family history of type 2 diabetes were significant predictors of incident GDM on multivariable analyses.
Conclusion
Mild elevations in antenatal TSH concentration did not significantly increase risk of incident GDM compared to healthy euthyroid women.

Keyword

Gestational diabetes; Hypothyroidism; Pregnancy; Maternal health; Antenatal screening

Reference

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