Korean J Parasitol.  2020 Apr;58(2):135-145. 10.3347/kjp.2020.58.2.135.

In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis

Affiliations
  • 1Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo León, Nuevo León 66455, México
  • 2Department of Analytic Chemistry, College of Medicine, Autonomous University of Nuevo León, Nuevo León 64460, México
  • 3Northeast Biomedical Research Center, Instituto Mexicano del Seguro Social, Nuevo León 64720, México

Abstract

Infections caused by Trichomonas vaginalis in humans are one of the main public health problems caused by sexually transmitted diseases. Objective of this study was to evaluate potential biological activity of the medicinal plant Argemone mexicana (Mexican poppy) on T. vaginalis. Methanolic extracts of the stems and leaves of A. mexicana, and different fractions were prepared with solvents of different polarities. The extracts and functional groups were detected containing sterols, triterpenes, quinones, flavonoids and, alkaloids. Extracts from both the stems and leaves of A. mexicana inhibited the growth of T. vaginalis with half-maximal inhibitory concentration value of 70.6 and 67.2 μg/ml, respectively. In the active fractions, the most abundant compounds were berberine and jatrorrhizine, with presumed antiparasitic activity.

Keyword

; ; trichomoniasis; alkaloids
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