Psychiatry Investig.  2020 May;17(5):417-423. 10.30773/pi.2020.0012.

The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

Affiliations
  • 1Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea
  • 2Department of Psychiatry, College of Medicine, Daegu Catholic University, Daegu, Republic of Korea
  • 3Department of Psychiatry, College of Medicine, Dongguk University, Gyeongju, Republic of Korea
  • 4Department of Psychiatry, Keimyung University School of Medicine, Daegu, Republic of Korea
  • 5Department of Psychiatry, College of Medicine, Yeungnam University, Daegu, Republic of Korea
  • 6Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

Abstract


Objective
Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality.
Methods
We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene.
Results
The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006).
Conclusion
This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.

Keyword

Suicide attempt, Lethality, Brain derived neurotrophic factor, Gene, rs6265
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