Ann Dermatol.  2020 Apr;32(2):146-150. 10.5021/ad.2020.32.2.146.

A Case of Solitary Fibrous Tumor of Subungual Region

  • 1Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.


Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm that usually arises in the pleura, but also has been reported in numerous extrapleural locations, including cutaneous site. The skin lesion presents as a circumscribed nodule or tumor, mainly on the head and neck. A 41-year-old male presented with 6 months history of nail lesion without symptom on the left third finger. The lesion is slightly yellowish discoloration with subungual erythematous nodule and distal onycholysis. Biopsy specimen from the nail lesion showed the spindle cells form patternless pattern with hypercellular and hypocellular area. And small blood vessels and dilated vascular spaces were present. The result of special stain for specimen showed that positive for CD34, Bcl-2, and CD99 but negative for S-100, FactorXIIIa, and smooth muscle action. Recognition of this uncommon location of SFT is important because of possible confusion with other subungual tumors, including glomus tumor, fibroma and other fibrohistiocytic tumors like dermatofibrosarcoma protuberans, superficial acral fibromyxoma and cellular digital fibroma. Here in, we report a case of SFT of subungual region. We think this case is interesting because of uncommon location and may be helpful to more understand the character of this disease.


Neoplasm; Solitary fibrous tumor

MeSH Terms

Blood Vessels
Glomus Tumor
Muscle, Smooth
Solitary Fibrous Tumors*


  • Fig. 1 Slightly yellowish discoloration with hypertrophic nail and distal onycholysis and erythematous subungual nodule on the proximal nail fold of left third finger.

  • Fig. 2 (A) The biopsy specimen shows proliferation of spindle cells and several small blood vessels and dilated vascular spaces are present (H&E, ×100). (B) The spindle cells form patternless pattern with hypercellular areas (H&E, ×200). (C) The spindle cells form patternless pattern with hypocellular areas (H&E, ×200). (D) The tumor cells are diffusely positive for CD34 (×400). (E) The tumor cells are positive for Bcl-2 (×400). (F) The tumor cells are diffusely positive for CD99 (×400). (G) The tumor cells are negative for S-100 (×400). (H) The tumor cells are negative for FactorXIIIa (×400). (I) The tumor cells are negative for SMA (×400).


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