J Korean Soc Traumatol.  2019 Dec;32(4):195-201. 10.20408/jti.2019.030.

Cranioplasty Results after the Use of a Polyester Urethane Dural Substitute (Neuro-Patch®) as an Adhesion Prevention Material in Traumatic Decompressive Craniectomy

Affiliations
  • 1Department of Trauma Surgery, Gachon University Gil Medical Center, Incheon, Korea. wkkim@gilhospital.com

Abstract

PURPOSE
This study was conducted to investigate the usefulness of a polyester urethane dural substitute (Neuro-Patch®, B. Braun, Boulogne, France) as an anti-adhesion agent in subsequent cranioplasty by analyzing the use of Neuro-Patch® during decompressive craniectomy in traumatic brain injury patients.
METHODS
We retrospectively analyzed patients with traumatic brain injury who underwent decompressive craniectomy followed by cranioplasty from January 2015 to December 2018. Patients were analyzed according to whether they received treatment with Neuro-Patch® or not (Neuro-Patch® group, n=71; control group, n=55). Patients' baseline characteristics were analyzed to identify factors that could affect cranioplasty results, including age, sex, hypertension, diabetes mellitus, use of antiplatelet agents or anticoagulant medication, the interval between craniectomy and cranioplasty, and the type of bone used in cranioplasty. The cranioplasty results were analyzed according to the following factors: operation time, blood loss, postoperative hospitalization period, surgical site infection, and revision surgery due to extra-axial hematoma.
RESULTS
No significant difference was found between the two groups regarding patients' baseline characteristics. For the cranioplasty procedures, the operation time (155 vs. 190 minutes, p=0.003), intraoperative blood loss (350 vs. 450 mL, p=0.012), and number of surgical site infections (4 vs. 11 cases, p=0.024) were significantly lower in the Neuro-Patch® group than in the control group.
CONCLUSIONS
The use of Neuro-Patch® was associated with a shorter operation time, less blood loss, and a lower number of surgical site infections in subsequent cranioplasties. These results may provide a rationale for prospective studies investigating the efficacy of Neuro-Patch®.

Keyword

Brain injuries, Traumatic; Craniotomy; Tissue adhesions; Intraoperative complications; Dura mater

MeSH Terms

Brain Injuries
Craniotomy
Decompressive Craniectomy*
Diabetes Mellitus
Dura Mater
Hematoma
Hospitalization
Humans
Hypertension
Intraoperative Complications
Platelet Aggregation Inhibitors
Polyesters*
Postoperative Hemorrhage
Prospective Studies
Retrospective Studies
Surgical Wound Infection
Tissue Adhesions
Urethane*
Platelet Aggregation Inhibitors
Polyesters
Urethane
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