J Korean Ophthalmol Soc.  2020 Jan;61(1):86-91. 10.3341/jkos.2020.61.1.86.

Risk Factors Associated with the Recurrence of Amblyopia after Successful Treatment

  • 1Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea. eyelovehyun@hanmail.net


We sought factors affecting amblyopia recurrence after successful treatment.
We included 117 patients with amblyopia. Patients were divided into recurrence and non-recurrence groups. We analyzed sex, age, amblyopia type, treatment duration, visual acuity, and binocular status.
Of the 117 patients, 25 (21.4%) experienced recurrences. In that group, 60.0% of patients (compared to 14.1% of the no-recurrence group) exhibited high-frequency strabismus (p < 0.001). The recurrence group were younger than the no-recurrence group at both the beginning and end of treatment (p < 0.05). None of visual acuity at treatment commencement or end, stereoacuity, or suppression affected amblyopia recurrence.
Recurrent amblyopia is frequent after initial successful treatment if the patient exhibits strabismus or is young.


Amblyopia; Recurrence; Risk factors

MeSH Terms

Risk Factors*
Visual Acuity


  • Figure 1 Comparison of recurrence patients according to the patient age. (A) Higher recurrence rate was observed in younger patients at start of treatment (p = 0.002*). (B) Higher recurrence rate was observed in younger patients at the end of treatment (p = 0.006*). *p-values by linear by linear association test.


1. von Noorden GK. Amblyopia: a multidisciplinary approach. Proctor lecture. Invest Ophthalmol Vis Sci. 1985; 26:1704–1716.
2. VereecKen EP, Brabant P. Prognosis for vision in amblyopia after loss of the good eye. Arch Ophthalmol. 1984; 102:220–224.
3. Pediatric Eye Disease Investigator Group. The clinical profile of moderate amblyopia in children younger than 7 years. Arch Ophthalmol. 2000; 120:281–287.
4. Oster JG, Simon JW, Jenkins P. When is it safe to stop patching. Br J Ophthalmol. 1990; 74:709–711.
5. Levartovsky S, Oliver M, Gottesman N, Shimshoni M. Factors affecting long term results of successfully treated amblyopia: initial visual acuity and type of amblyopia. Br J Ophthalmol. 1995; 79:225–228.
6. Holmes JM, Beck RW, Kraker RT, et al. Risk of amblyopia recurrence after cessation of treatment. J AAPOS. 2004; 8:420–428.
7. Bhola R, Keech RV, Kutschke P, et al. Recurrence of amblyopia after occlusion therapy. Ophthalmology. 2006; 113:2097–2100.
8. Nilsson J, Baumann M, Sjöstrand J. Strabismus might be a risk factor for amblyopia recurrence. J AAPOS. 2007; 11:240–242.
9. Woo KJ, Choi MY. The clinical features with recurrence of amblyopia after cessation of amblyopic treatment. J Korean Ophthalmol Soc. 2009; 50:1705–1711.
10. Flynn JT, Woodruff G, Thompson JR, et al. The therapy of amblyopia: an analysis comparing the results of amblyopia therapy utilizing two pooled data sets. Trans Am Ophthalmol Soc. 1999; 97:373–390. discussion 390-5.
11. Levartovsky S, Gottesman N, Shimshoni M, Oliver M. Factors affecting long term results of successfully treated amblyopia: age at beginning of treatment and age at cessation of monitoring. J Pediatr Ophthalmol Strabismus. 1992; 29:219–223.
12. Woodruff G, HIscox F, Thompson JR, Smith LK. Factors affecting the outcome of children treated for amblyopia. Eye (Lond). 1994; 8(Pt 6):627–631.
13. Jastrzebski GB, Hoyt CS, Marg E. Stimulus deprivation amblyopia in children. Sensitivity, plasticity, and elasticity (SPE). Arch Ophthalmol. 1984; 102:1030–1034.
14. Daw NW. Critical periods and amblyopia. Arch Ophthalmol. 1998; 116:502–505.
15. Tacagni DJ, Stewart CE, Moseley MJ, Fielder AR. Factors affecting stability of visual function following cessation of occlusion therapy for amblyopia. Graefes Arch Clin Exp Ophthalmol. 2007; 245:811–816.
16. Ching FC, Park MM, Friendly DS. Practical management of amblyopia. J Pediatr Ophthamol Strabismus. 1986; 23:12–16.
17. Levartovsky S, Oliver M, Gottesman N, Shimshoni M. Long-term effect of hypermetropic anisometropia on the visual acuity of treated amblyopic eyes. Br J Ophthalmol. 1998; 82:55–58.
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