Infect Chemother.
2019 Dec;51(4):393-398. 10.3947/ic.2019.51.4.393.
Comparison of Characteristics and Survival between Prospective and Retrospective Korea Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Cohort Studies
- Affiliations
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- 1Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. SERAN@yuhs.ac
- 2Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
- 5Division of Infectious Disease, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 6Division of Viral Disease Research, Center for Infectious Diseases Research, Korea, National Institute of Health, Cheongju, Korea.
- KMID: 2466472
- DOI: http://doi.org/10.3947/ic.2019.51.4.393
Abstract
- By comparing the data of prospectively and retrospectively enrolled cohorts, we evaluated whether the prospective cohort represented all patients in the retrospective cohort. The prospectively enrolled subjects were older and had lower CD4+ T cell counts, higher viral load. In addition, the initial antiretroviral treatment regimen of the prospective cohort consisted of less integrase strand transfer inhibitor-containing regimens. The 20-year survival rate was 51.8% in the prospective cohort and 84.6% in the retrospective cohort, respectively (P = 0.844). This study suggests the prospective cohort study may not represent all patients.
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