Infect Chemother.  2019 Dec;51(4):393-398. 10.3947/ic.2019.51.4.393.

Comparison of Characteristics and Survival between Prospective and Retrospective Korea Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Cohort Studies

• Kim JH
• Choi Y
• Song JY
• Kim SW
• Kim SI
• Kee MK
• Choi BY
• Choi JY

• KMID: 2466472
• DOI: http://doi.org/10.3947/ic.2019.51.4.393

Abstract

By comparing the data of prospectively and retrospectively enrolled cohorts, we evaluated whether the prospective cohort represented all patients in the retrospective cohort. The prospectively enrolled subjects were older and had lower CD4+ T cell counts, higher viral load. In addition, the initial antiretroviral treatment regimen of the prospective cohort consisted of less integrase strand transfer inhibitor-containing regimens. The 20-year survival rate was 51.8% in the prospective cohort and 84.6% in the retrospective cohort, respectively (P = 0.844). This study suggests the prospective cohort study may not represent all patients.

Keyword

HIV/AIDS; Cohort study; Survival rates

MeSH Terms

Cell Count
Cohort Studies*
Humans*
Integrases
Korea*
Prospective Studies*
Retrospective Studies*
Survival Rate
Viral Load
Integrases

Figure

• 

  Figure 1 Kaplan-Meier curve comparing survival rates of the prospective and retrospective cohorts.

Reference

1. Prentice RL. Design issues in cohort studies. Stat Methods Med Res. 1995; 4:273–292.

2. Howe CJ, Cole SR, Lau B, Napravnik S, Eron JJ Jr. Selection bias due to loss to follow up in cohort studies. Epidemiology. 2016; 27:91–97.

3. Schooling CM, Cowling BJ, Jones HE. Selection bias in cohorts of cases. Prev Med. 2013; 57:247–248.

4. Grimes DA, Schulz KF. Cohort studies: marching towards outcomes. Lancet. 2002; 359:341–345.

5. Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004; 15:615–625.

6. Song JY, Lee JS, Jeong HW, Choi HJ, Lee JS, Lee J, Eom JS, Cheong HJ, Chung MH, Kim WJ. Comparison of HIV-infected patients' characteristics and clinical outcomes between cohort-dependent and independent patients: Korean HIV cohort study. J Acquir Immune Defic Syndr. 2011; 57:e61–e63.

7. Kim YJ, Woo JH, Kim MJ, Park DW, Song JY, Kim SW, Choi JY, Kim JM, Han SH, Lee JS, Choi BY, Lee JS, Kim SS, Kee MK, Kang MW, Kim SI. Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013. Korean J Intern Med. 2016; 31:953–960.

8. Choi BY, Choi JY, Han SH, Kim SI, Kee MK, Kim MJ, Kim SW, Kim SS, Kim YM, Ku NS, Lee JS, Lee JS, Choi Y, Park KS, Song JY, Woo JH, Kang MW, Kim J. Korea HIV/AIDS Cohort Study: study design and baseline characteristics. Epidemiol Health. 2018; 40:e2018023.

9. Kalsbeek W, Heiss G. Building bridges between populations and samples in epidemiological studies. Annu Rev Public Health. 2000; 21:147–169.