J Pathol Transl Med.  2019 Mar;53(2):148-151. 10.4132/jptm.2019.01.15.

Metastatic Insulinoma Presenting as a Liver Cyst

Affiliations
  • 1Department of Pathology and Laboratory Medicine Albany Medical Center, Albany, NY, USA. LeeH5@amc.edu
  • 2Department of General Surgery, Albany Medical Center, Albany, NY, USA.

Abstract

No abstract available.


MeSH Terms

Insulinoma*
Liver*

Figure

  • Fig. 1. Computed tomography shows one of the metastatic nodules (*) and a cyst (**) in the liver.

  • Fig. 2. Primary pancreatic neuroendocrine tumor and hepatic metastasis. (A) Scanning view of the tumor in the pancreas. (B) Higher magnification view shows “salt and pepper” chromatin pattern of the tumor cells. (C) Scanning view of the solid hepatic metastasis. (D) Higher magnification view of the hepatic metastasis shows trabecular growth pattern.

  • Fig. 3. Hepatic cystic metastasis of pancreatic well-differentiated neuroendocrine tumor. (A) Scanning view shows cyst walls. (B–D) Mediumpower view demonstrates neoplastic cells lining the cyst (B) that are positive for synaptophysin (C) and cytokeratin AE1/AE3 (D).


Reference

1. Halfdanarson TR, Rubin J, Farnell MB, Grant CS, Petersen GM. Pancreatic endocrine neoplasms: epidemiology and prognosis of pancreatic endocrine tumors. Endocr Relat Cancer. 2008; 15:409–27.
Article
2. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. 4th ed. Lyon: International Agency for Research on Cancer;2010. p. 322–6.
3. Halfdanarson TR, Rabe KG, Rubin J, Petersen GM. Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Ann Oncol. 2008; 19:1727–33.
Article
4. Zhang X, Song J, Liu P, et al. A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study. BMC Endocr Disord. 2018; 18:73.
Article
5. Cloyd JM, Kopecky KE, Norton JA, et al. Neuroendocrine tumors of the pancreas: degree of cystic component predicts prognosis. Surgery. 2016; 160:708–13.
Article
6. Fiori S, Del Gobbo A, Gaudioso G, et al. Hepatic pseudocystic metastasis of well-differentiated ileal neuroendocrine tumor: a case report with review of the literature. Diagn Pathol. 2013; 8:148.
Article
7. Isomura T, Kojiro M, Kawano Y, et al. Small multiple carcinoid tumors occurring in the ileum with a pseuodcystic liver metastasis. Acta Pathol Jpn. 1980; 30:137–43.
8. Yoshioka M, Shibata S, Uchinami H, et al. The transformation of a nonfunctioning islet cell tumor of the pancreas into a proinsulinoma under conditions of lung metastasis. Intern Med. 2015; 54:785–90.
Article
9. Bozkirli E, Bakiner O, Abali H, et al. A case of inoperable malignant insulinoma with resistant hypoglycemia who experienced the most significant clinical improvement with everolimus. Case Rep Endocrinol. 2013; 2013:636175.
Article
10. Alexandraki K, Angelousi A, Boutzios G, Kyriakopoulos G, Rontogianni D, Kaltsas G. Management of neuroendocrine tumors of unknown primary. Rev Endocr Metab Disord. 2017; 18:423–31.
Article
Full Text Links
  • JPTM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr