J Korean Orthop Assoc.  1968 Feb;3(1):55-61. 10.4055/jkoa.1968.3.1.55.

An experimental study of stimulation of the growth of a lone bone

Abstract

The operative lengthening of the diseased side or stimulation of growth rather than the operative shortening of a normal side or inhibition of growth has been considered an idealistic treatment for the inequaIity in length of the lower extremity in the orthopedic field. I have attempted to stimulate a process of bone growth of epiphyseal plate of an experimental growing animal above the normal size by the following methods: 1. To insert Kirschners wire in the distal portions of the metaphysis and epiphysis of a rab it. 2. To install a traction apparatus on the afore-mentioned Kirschner's wire. 3. To insert a silver jingle bell with 7mm-diameter in the distal epiphyis af a puppys femoral. bone. Results of the experiments: The first and second experiment have proven that the skeletal traction did not contribute anything to stimulation and inhibition of a bone growth, although the two experiments have shown approximately 0.5 mm stimulation growth on 60% of the whole disregarding the effectiveness of traction apparatus between the Kirschners wire. In the third experiment tohe sonic stimulative effect on the epiphysis of the puppys femur with the insertion of the jingle bell has also failed to stimulate and inhibit a bone growth.


MeSH Terms

Animals
Bone Development
Epiphyses
Femur
Growth Plate
Lower Extremity
Orthopedics
Silver
Traction
Silver

Reference

References

(2). Barr J.S., Stinchfield A.J., Reidy J.A.Sympathetic ganglionectomy and limb length in poliomyelitis. J. Bone & Joint Surg. 32–A:798–802. 1950.
(3). Bertrand P.,, Trillat A.Traitement desine–glites de longueur des membres inferieurs pendant lacroissance. Rev. Orthop. 34:264–311. 1948.
Article
(4). Blount W.P.Inequality in length of lower extremities. Significance of leg length in poliomyelitis. In Campbell’s operative orthopedics, 3rd ed. e.v. Mosby;1829–1869. 1956.
Article
(5). Blount W.P.,, Clarke G.R.Control of bone growth by epiphyseal stapling. J. Bone Joint Surg. 31–A(3):1949.
Article
(6). Bohlman H.R.Experiments with foreign materials in region of epiphyseal cartilage plate of growing bones to increase their longitudinal growth. J. Bone & Joint Surg. 11:365–384. 1929. (cited from).
(7). Bost F.C.,, Larsen L.J.Experiences with lengthening of the femur over an intramedullaryrod. J. Bone & Joint Surg. 38–A:567. 1956.
Article
(8). Brooks M.Femoral growth after occlusion of principal nutrient canal in day-old rabbits. J. Bone Joint Surg. 36–B:568–571. 1957.
Article
(9). Carpenter E.B.,, Dalton J.B. Jr.A critical evaluation of a methdo of epiphyseal stimulation. J. Bone & Joint Surg. 38–A:1089. 1956.
(10). Chapchal G.,, Zeldenrust J.Experimental research for promoting longitudinal growth of the lower extremities by irritation of the growth region of femur and tibia. Acta Orthop. Scandinav. 17:371–396. 1948.
Article
(13). Compere E.L.,, Adams CO.Studies of lon gitudinal growth of long bones. l. The influence of trauma to the diaphysis. J. Bone & Joint Surg. 19:922–936. 1937.
(14). De Forest R.E., Herrick J.F., Janes J.M., Krusen F.H.Effects of ultrasound on growing bone; experimental study. Arch. Phys. Med. 34:21. 31. 1953.
(15). Doyle J.R.Stimulation of bone growth by short-wave diathermy. J. Bone & Joint Surg. 43–A:314. 1961.
Article
(16). Doyle J.R.,, Smark B.W.Stimulation of bone growth by short-wave diathermy. J. Bone and Joint Surg. 45–A(1):1963.
(17). Ferguson A.B.Surgical stimulation of bone growth by a new procedure. Preliminary report. J. A.M.A. 10:26. 1933.
(18). Gelbke H.The influence of pressure and tension on growing bone in experiments with animals. J. Bone & Joint Surg. 33–A:947–954. 1951.
(19). Green W.T.,, Miss Anderson M.The correction of discrepancies in growth of the lower extremities. J. Bone & Joint Surg. 37–A:637. 1955.
(20). Guerriero C.Richerche spermentali sull azione delle emulsioni di germi piogeni sulla cartildginedi coniugazione. Ann. Ital. Chiro. 6:388–411. 1927.
(21). Haas S.L.Stimulation of bone growth. J. Bone & Joint Surg. 37–A:636. 1955.
Article
(22). Haas S.L.Stimulation of bone growth. J. Bins & Joint Surg. 95:125–131. 1958.
Article
(23). Harris R.I.Effect of lumbar sympathectomy on growth of legs shortedned from anterior poliomyelitis, preliminary report. J. Bone and Joint Surg. 12:859–866. 1930.
(24). Harris R.I.,, McDonald J.L.Effect of lumbar sympathectomy upon growth of legs paralzed by anterior poliomyelitis. J. Bone. & Joint Surg. 18:35–45. 1936.
(25). Herndon C.H.,, Spencer G.E.An experimental attempt to stimulate linear growth of long bones in rabbits. J. Bone & Joint Surg. 35–A:758–759. 1953.
(26). Hiertonn T.Arteriovenous anastomosis and acceleration of Bone growth. Acta, Orthop. Scand. 26:322. 1957.
(27). Hutchison W.J.,, Burdeaux B.D. Jr.The influence of stasis on bone growth. Surgery Gynecology and Obstetrics. 99:413. 1954.
(28). Janes J.M.,, Musgrove J.E.Effects of arteriovenous fistula on growth of bone. Surg. Clin. N. Amer. 30:1191–1200. 1950.
Article
(29). Jansen K.Inhibition and stimulation of growth. Acta. Orthop. Scand. 26:296–308. 1957.
(30). Kelly P.J., Peterson L. F. A., Janes J.M.Ultrastructure of bone: Technic of microradiography and it’s possible application to the study of bone. Staff Meetings of the Mayo Clinic. 32:687–690. 1957.
(31). Kelly P.J.,, Peterson J.The effect of arteriovenous fistula on thevascular pattern of the femora of immature dogs. A microangiogr aphic study. J. Bone & Joint Surg. 41–A:1101–1108. 1959.
(32). Kelly P.J., Phil J.D., Riggs B.L.A comparison of different morphologic methods of determining bone formation. Clin. Orthop. 1965.
Article
(33). Key J. A., Ford L.T.A study of experimental trauma to the distal femoral epiphysis in rabbits. J. Bone and Joint Surg. 40–A(4):1958.
(34). Konigswieser . Experimenelle und pathologische Beinflussing des Epi physenwachstums. Verhandl. Dent. Orth. Ges. 20:285. 1925.
(35). Kramer W.G.Epiphseal stimulation in lower extremities. Calif. Med. 83:424–426. 1955.
(36). Langenskiöld A.Inhibition and stimulation of bone growth. Acta Or thop. Scand. 26:308–316. 1957.
(37). Meisenbach R.O.A consideration of the clinical and mechanical stimulation of bone with reference to the epiphyseal and diaphyseal lines, Results of animal experimentation. Am. J. Orthop. Surg. 8:29–94. 1910.
(38). Milch R.A.,, Tobie J.E.Fluorescence of tetracyline antibiotics in bone. J. Bone & Joint Surg. 40–A:897. 1958.
(39). Pease C.N.Local stimulation of growth of long bones. A preliminary report. J. Bone & Joint Surg. 43–A:1–23. 1952.
(40). Pease C.N.Discussion of critical evaluation of method of epiphyseal stimulation. Carpenter E. B., Dalton J. B., editorsJ. Bone & Joint Surg. 38–A:1095. 1956.
(41). Pearse H.E.,, Morton J.J.The stimulation of bone growth by venous stasis. J. Bone & Joint Surg. 12:97–111. 1930.
(42). Peterson L. F. A., Nehr M., Janes J. M., kelly and P.J.A stereoscopic microradiographic camera with vaccum filmholder and a stereomicroscope. Staff Meeting of the Mayo Clinic. 34:282–289. 1959.
(43). Ray R.O.. Growth and differentiation of the skeletone in tkyroidectomized-hypophysectomized rats treated with thyroxin, growth hormone and combination. J. Bone & Joint Surg. 36–A:94–103. 1954.
(44). Ring P. A.The influence of the nervous system upon the growth of bone. J, Bone & Joint Surg. 43–B:121. 1961.
(45). Schneider M.Experimental epiphyseal arrest by intraosseous injection of Papain. J. Bone & Joint Surg. 45–A(1):1963.
Article
(46). Stahl F.Plugging of marrow cavity of tibia for stimulating growth in length. Acta Orthop. Scand. 26:322–324. 1957.
(47). Trout H.H.Autogenous bone graft verus Lanes plates. Ann. Surg. 61:717–727. 1915.
(48). Trueta J. Influence of blood supply in controlling bone growth. Bull. Hosp. Jt. dis. (N. Y.). 14:147–157. 1953.
(49). Vanderhoeft P.J., Peterson L. F. A., Kelly P.J. A method for correlative analysis of micr or adiogram and tetracycline fluorophore of puppy’s bone. Staff Meetings the Mayo Clinic. 37:229–235. 1962.
(50). Von Langenbeck B.Ueber Krankhaftes Lngenwachstum der Röhrenknochen und seine Verwerth-nug für die Chirurgische Praxis. Berl. Klin. Wcknschr. 6:265–270. 1869.
(51). Wilson C.L.Experimental increase in leg length. A preliminary report, American College of Surgeons,. 1951:438–443. 1952.
(52). Wilson C. L., Percy E. C.Experimental studies on epiphyseal stimulation. J. of Bone & Joint Surg. 38–A:1096. 1956.
Article
(53). Wu Y.K.,, Miltner L.J.A procedure for stimvlation of longitudinal growth on bone. An experimental study. J. Bone & Joint Surg. 19:909–921. 1937.
(54). Ollier L.Tratte experimental et clinique de la regeneration des os et de la Production artificalle du tissu Osseux. I. mason, Paris. 1967.
(55). Eio J.O.The effect of subperiosteally implanted autogenous whole thickness skin graft on growing bone. An experimental study, Acta Orthop. Scand. 30(45):1960.
Full Text Links
  • JKOA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr