Tissue Eng Regen Med.  2019 Oct;16(5):451-465. 10.1007/s13770-019-00218-7.

Multimodal Composite Iron Oxide Nanoparticles for Biomedical Applications

Affiliations
  • 1Department of Biomedical Science, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea. pik96@jnu.ac.kr
  • 2Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.
  • 3Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Chonnam 58128, Republic of Korea. yskoh@chonnam.ac.kr
  • 4Department of Chemical and Biomedical Engineering, Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, USA. s.lee67@csuohio.edu

Abstract

BACKGROUND
Iron oxide nanoparticles (IONPs) are excellent candidates for biomedical imaging because of unique characteristics like enhanced colloidal stability and excellent in vivo biocompatibility. Over the last decade, material scientists have developed IONPs with better imaging and enhanced optical absorbance properties by tuning their sizes, shape, phases, and surface characterizations. Since IONPs could be detected with magnetic resonance imaging, various attempts have been made to combine other imaging modalities, thereby creating a high-resolution imaging platform. Composite IONPs (CIONPs) comprising IONP cores with polymeric or inorganic coatings have recently been documented as a promising modality for therapeutic applications.
METHODS
In this review, we provide an overview of the recent advances in CIONPs for multimodal imaging and focus on the therapeutic applications of CIONPs.
RESULTS
CIONPs with phototherapeutics, IONP-based nanoparticles are used for theranostic application via imaging guided photothermal therapy.
CONCLUSION
CIONP-based nanoparticles are known for theranostic application, longstanding effects of composite NPs in in vivo systems should also be studied. Once such issues are fixed, multifunctional CIONP-based applications can be extended for theranostics of diverse medical diseases in the future.

Keyword

Iron oxide nanoparticles; Magnetic resonance imaging; Ultrasound imaging; Photoacoustic imaging; Optical imaging

MeSH Terms

Colloids
Iron*
Magnetic Resonance Imaging
Multimodal Imaging
Nanoparticles*
Optical Imaging
Polymers
Theranostic Nanomedicine
Ultrasonography
Colloids
Iron
Polymers
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